143. The optical rotatory powers of (+)-γ-methyl-n-heptane

Kenyon, Joseph; Platt, Bertie C.

doi:10.1039/jr9390000633

Cited by 22 publications

(8 citation statements)

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“…This is the summary of mutagenic/carcinogenic activities of DEHP and MEHP on microorganisms and on hamster cells. (7) and was more than 99% pure as determined by ECD-GLC analysis. Plastic dishes and flasks for tissue culture were obtained from Falcon Plastic (Oxnard, Calif.).…”

Section: Introduction the Mutagenic Activity Of Di(2-ethylhexyl) Phthmentioning

confidence: 99%

Mutagenic/Carcinogenic Potential of DEHP and MEHP

Tomita¹,

Nakamura²,

Aoki³

et al. 1982

Environmental Health Perspectives

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Section: Introduction the Mutagenic Activity Of Di(2-ethylhexyl) Phthmentioning

confidence: 99%

Mutagenic/Carcinogenic Potential of DEHP and MEHP

Tomita¹,

Nakamura²,

Aoki³

et al. 1982

Environmental Health Perspectives

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“…DEHP was analyzed by GLC by Dr. Gary Muschik (Program Resources Inc., FCRF, Frederick, MD, USA) and found to be 99% pure. MEHP was synthesized by a slight modification of the method described by Kenyon and Platt (12), and was analyzed by FID/GLC and found to be 96% pure. For in vitro assays, DEHP was mixed with acetone, while MEHP and EH were dissolved in DMSO.…”

Section: Chemicalsmentioning

confidence: 99%

Tumor-Initiating and Promoting Activities of Di(2-Ethylhexyl) Phthalate in Vivo and in Vitro

Ward¹,

Diwan²,

Ohshima³

et al. 1986

Environmental Health Perspectives

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The carcinogenic effects of di(2-ethylhexyl) phthalate (DEHP), including its potential as an initiator and as a promoter of carcinogenesis, were studied in mouse liver and skin and in rat liver in vivo, and in mouse epidermis-derived JB6 cells in vitro. A mouse model for liver initiation and promotion involved initiation by injection ofN-nitrosodiethylamine (DEN) intraperitoneally into male B6C3F1 mice at 4 weeks of age, followed by exposure to either DEHP in the diet (3000, 6000, or 12,000 ppm) or phenobarbital in the drinking water (500 ppm), beginning 1 to 2 weeks later and continuing for periods of from 1 day to 18 months. Female F344/ NCr rats were subjected to a similar protocol in which promotion continued for 14 weeks. DEHP promoted focal hepatocellular proliferative lesions (FHPL), including hyperplastic foci and neoplasms initiated by DEN in mice but not in rats. Skin-painting studies in female CD-1 or SENCAR mice involved initiation by a single topical exposure to 7,12-dimethylbenz[aI-anthracene (DMBA) applied to the dorsal skin, followed by repeated percutaneous exposure to a tumor promoter, either DEHP or 12-O-tetradecanoylphorbol-13-acetate (TPA). To test for two-stage skin tumor promotion, SENCAR mice were initiated with DMBA and then TPA was administered for only 2 weeks, after which DEHP was subsequently administered for 26 weeks. DEHP displayed very weak complete promoting activity and definite second stage promoting activity in SENCAR mouse skin, but was inactive under our conditions on CD-1 mouse skin. In vitro promoting activity of DEHP and its hydrolysis products, mono(2-ethylhexyl) phthalate (MEHP) and 2-ethylhexanol (EH), was studied by using promotable mouse epidermis-derived JB6 cells. DEHP and MEHP promoted JB6 cells to anchorage independence, while EH did not.

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“…a-Ethylhexanoic acid, b.p. 220-2220, was prepared by the oxidation of commercial 2-ethyl-n-hexanol by method (a) of Kenyon & Platt (1939). Pregnane-3a:20oc-diol was generously presented by Dr J. K. Grant, and sodium pregnanediol glucuronidate was a specimen from the Medical Research Council steroid collection.…”

Section: Experimental Materialsmentioning

confidence: 99%