142b: The Relationship Between Keloid Growth Pattern and Stretching Tension-Visual Analysis Using the Finite Element Method

Akaishi, Satoshi; Akimoto, Makio; Ogawa, Rei

doi:10.1097/01.prs.0000371876.11202.fe

Cited by 37 publications

(49 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The gentle reduction in tension which can be provided by an adhesive SGS provides the ideal environment for normal scar development and can significantly reduce the rate of abnormal and keloid scarring. 22 Other treatments have the potential to apply too much or misplaced tension reduction, resulting in a poorer performance. 23 SGS has also been found to inhibit the body's natural reaction to increase skin capillaries through hyperemia.…”

Section: Mechanisms Of Action Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

View full text Add to dashboard Cite

Significance: This article discusses the history and developments of silicone gel sheeting (SGS) scar therapy. Furthermore, we review a breadth of literature to gain an insight into how and why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance. Recent Advances: Topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. SGS has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. Critical Issues: While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed at present. However, there still is ongoing deliberation over the exact mechanism of action of silicone in improving a scar. At present it is likely that through occlusion of the scar site and hydration of the wound bed, the overactivity of scar-related cells is suppressed, and their activity normalized. Future Direction: The clinical support of topical silicone gel products, relative to all alternative scar therapies, is considered the internationally recommended first-line form of scar management, and favored by consensus among healthcare professionals. However, there still remains the need for further clinical evidence and a better understanding of the mechanism behind the benefit of silicone gel for use in the prevention of abnormal scarring. SCOPE AND SIGNIFICANCESilicone gel sheeting (SGS) has been used in scar therapy for over 30 years, during which its efficacy has been the subject of numerous clinical evaluations. While the exact mechanisms by which SGS improves hypertrophic scars, keloid development and recovery are yet to be fully agreed upon, its ability to do so remains largely undisputed. As such, topical silicone gel treatments seem to remain the first point of clinical recommendation in scar management. This article aims to review a breadth of literature to gain an insight not only into how, but also why topical silicone gels remain the favored treatment of medical experts in scar management. We also analyze an ever increasing number of alternative therapies claiming to provide enhanced scar reduction performance as a comparison. TRANSLATIONAL RELEVANCESilicone has been used for more than 30 years in the treatment of cutaneous scars.1 New formulations and formats of silicone gel products are becoming available for use in the treatment of scarring resulting from surgery, burns, and other skin injuries requiring hospital treatment.

show abstract

Section: Mechanisms Of Action Of Sgsmentioning

confidence: 99%

The Use of Silicone Adhesives for Scar Reduction

Bleasdale¹,

Finnegan

Murray

et al. 2015

Advances in Wound Care

View full text Add to dashboard Cite

show abstract

“…First, keloids commonly adopt distinct site-specific shapes, namely, the typical butterfly, crab's claw, and dumbbell shapes on the shoulder, anterior chest, and upper arm, respectively. This, together with our visual analysis using the finite element method, suggests that keloids are largely determined by the direction of the tension that is applied to the skin around the wound site 13 . Second, keloids show a marked preference for particular locations on the body: they usually occur at sites that are constantly or frequently sub- …”

Section: Pathogenesis Of Keloids and Hypertrophic Scarsmentioning

confidence: 99%

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy

et al. 2016

View full text Add to dashboard Cite

Keloids and hypertrophic scars are fibroproliferative disorders of the skin that are caused by abnormal healing of injured or irritated skin. It is possible that they are both manifestations of the same fibroproliferative skin disorder and just differ in terms of the intensity and duration of inflammation. These features may in turn be influenced by genetic, systemic, and local risk factors. Genetic factors may include single nucleotide polymorphisms, while systemic factors may include hypertension, pregnancy, hormones, and cytokines. The most important local factor is tension on the scar. Over the past 10 years, our understanding of the pathogenesis of keloids and hypertrophic scars has improved markedly. As a result, these previously intractable scars are now regarded as being treatable. There are many therapeutic options, including surgery, radiation, corticosteroids, 5-fluorouracil, cryotherapy, laser therapy, antiallergy agents, anti-inflammatory agents, bleaching creams and make-up therapies. However, at present, we believe that the following combination of three therapies most reliably achieves a complete cure: surgery, followed by radiation and the use of steroid tape/plaster. (J Nippon Med Sch 2016; 83: 46 53)

show abstract

“…Simulation using finite element models is an established method in the field of biomechanics, and is used for evaluation of dynamic functions of various organs, such as bones, [10][11][12][13][14] the thorax, [15] and soft tissues. [16,17] Despite its proven usefulness, we still need to examine the validity of finite element simulation when we use it as the main technique of a study. Hence, we conducted the verification examination and proved the validity of the present study's methods.…”

Section: Methodological Considerationsmentioning

confidence: 99%

A biomechanical study of relationship between sternum defect patterns and thoracic respiration

Nagasao

Kasai

Shimizu

et al. 2016

Computer Assisted Surgery

View full text Add to dashboard Cite

Background: Various types of sternum defects are produced after the removal of thoracic tumors involving the sternum. The present study aims to elucidate the relationship between the defect patterns and their effects on thoracic respiration. Methods: Ten sets of finite element models were produced simulating thoraces of 10 persons and termed normal models. With each of the 10 normal models, the sternum was removed in six different ways to produce new models termed defect models. Defect models were categorized into hemi-superior (H-S), hemi-inferior (H-I), hemi-whole length (H-W), bilateral-superior (B-S), bilateralinferior (B-I), and bilateral-whole length (B-W) defect types, depending on the locations of the defects. Respiratory movement was dynamically simulated with these models. The volume change the thoraces present during respiration was measured to evaluate the effectiveness of thoracic respiration. This value -defined as DV -was calculated and was compared between normal and defect models. Results: With H-W and B-W type models, DV dropped to around 20% of normal values. With H-S and B-S type models, DV dropped to around 50% of normal values. With H-I and B-I type models, DV presented values almost equivalent to those of normal models. Conclusion: Effectiveness of thoracic respiration is seriously impaired when the whole length of the sternum is absent. Reconstruction of the defect is essential for these cases. However, since the upper part of the sternum is most important for effective thoracic respiration, priority should be placed on the upper part in performing reconstruction.

show abstract

142b: The Relationship Between Keloid Growth Pattern and Stretching Tension-Visual Analysis Using the Finite Element Method

Cited by 37 publications

References 0 publications

The Use of Silicone Adhesives for Scar Reduction

The Use of Silicone Adhesives for Scar Reduction

Keloids and Hypertrophic Scars Can Now Be Cured Completely: Recent Progress in Our Understanding of the Pathogenesis of Keloids and Hypertrophic Scars and the Most Promising Current Therapeutic Strategy

A biomechanical study of relationship between sternum defect patterns and thoracic respiration

Contact Info

Product

Resources

About