141 Hepatic Lesions in Childhood Celiac Disease (Cd)

Autoimmune Hepatitis Associated with Celiac Disease in Childhood: Report of Two Cases

“…Non‐specific hepatitis, with slight elevation of serum aminotransferase levels, is quite common in celiac disease 1 . It usually represents a benign condition called gluten hepatitis in which high aminotransferase levels are resolved with a gluten‐free diet.…”

“…The relationship between gluten hepatitis and celiac disease is well known and has been documented both in adults and children, ranging from 1.3 to 68% 1 . The association between celiac disease and autoimmune hepatic disease, primary biliary cirrhosis and primary sclerosing cholangitis is less frequent 3 .…”

A Case of Celiac Disease Presenting With Autoimmune Hepatitis and Erythroblastopenia

“…No autoimmunity was documented in these three children. In an Italian, multicenter study coordinated by Maggiore et al (14) during a 5‐year period, 27 children out of 2,000 with CD presented with hypertransaminasemia. Histologic tests performed in 9 children, revealed 3 cases of cirrhosis (2 of these patients had antiendoplasmic reticulum Ab).…”

“…The prothrombin time was 80 seconds. Blood immunoglobulins were increased: IgG, 24.9 g/L (normal, [5][6][7][8][9][10][11][12][13][14]. ␣ 1 -Antitrypsin, ceruloplasmin, and blood copper concentrations were normal.…”

Graves' disease, Celiac disease and liver function abnormalities in a patient--clinical manifestation and diagnostic difficulties.

“…They may be within the spectrum of the clinical manifestation of the same disease, where congenital factors and gluten exposure may influence the pattern of liver dysfunction, or may reflect liver abnormalities of different pathogenesis. Non-specific hepatitis with moderate increase in aminotransferases activity is a quite common clinical entity in celiac disease (CD) (Lindberg et al, 1978;Maggiore et al, 1994).…”