Abstract:White adipose tissue is characterized by substantial functional heterogeneity based on anatomic location and developmental lineages. Such differences may contribute to depot-dependent differences in adipose regulation of systemic metabolism and the relative impact of adipose distribution (e.g. subcutaneous, SQ, vs. intraabdominal, IA) on risk for type 2 diabetes. While mouse adipose depot heterogeneity at the single-cell level has recently been explored, comparative analysis of human white fat depots is still … Show more
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