140. the Vasculitis Pregnancy Registry (Vpreg): Baseline Information for the First 3 Years

Golenbiewski, Jon; Young, Kalen; Burroughs, Cristina; Kullman, Joyce; Merkel, Peter A.; Clowse, Megan E.B.

doi:10.1093/rheumatology/kez059.017

Cited by 2 publications

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“…Data from pregnant patients with AAV mostly derive from case reports or retrospective studies. Since 2015, the Vasculitis Pregnancy Registry (V-PREG) collects data on pregnant women with several different vasculitides, including 24 patients with AAV in the first 3 years [ 5 ]. On this basis, there are no official monitoring or treatment recommendations for women with AAV who want to become or are pregnant.…”

Section: Introductionmentioning

confidence: 99%

Optimal management of ANCA-associated vasculitis before and during pregnancy: current perspectives

Pecher¹,

Henes

Henes³

2022

Arch Gynecol Obstet

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Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a group of systemic vasculitis characterized by autoantibodies against neutrophil cytoplasmic antigens (proteinase 3 PR3-ANCA and myeloperoxidase MPO-ANCA) and inflammation of small vessels. AAV include the diagnosis Granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), which share many clinical and pathological features. Immunomodulatory therapies have significantly improved prognosis during the last decade. Nevertheless, especially in undiagnosed and thus uncontrolled AAV mortality due to renal impairment or pulmonary haemorrhages is still high. AAV are rare in fertile women, as the typical age of manifestation is above 50 years but there are women with AAV who are or want to become pregnant. This review focusses on how to manage patients with AAV planning to become pregnant and during their pregnancy.

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Section: Introductionmentioning

confidence: 99%

Optimal management of ANCA-associated vasculitis before and during pregnancy: current perspectives

Pecher¹,

Henes

Henes³

2022

Arch Gynecol Obstet

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Pregnancy Outcomes in Systemic Vasculitides

2020

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Purpose of Review In recent years, improvements in the recognition of primary vasculitides and increased treatment options have led to greater survival rates and a better quality of life for patients. Therefore, pregnancy in women with vasculitis has become a more frequent consideration or event. Literature on pregnancy outcomes in this population has grown and allowed us, in this article, to review the effects of pregnancy on disease activity, as well as maternal and fetal outcomes for each type of vasculitides. Recent Findings Successful pregnancies in patients with vasculitides are possible, especially when conception is planned, and the disease is in remission. The risk of vasculitis flare is highly dependent on the type of vasculitis, but overall limited. The most frequent complication associated with large-vessel vasculitis (mainly Takayasu arteritis) is hypertension and preeclampsia. Preterm deliveries and intrauterine growth restriction occur more frequently with small-and medium-vessel vasculitis. Summary Pregnancies in patients with vasculitis should be considered high risk and followed by a multidisciplinary team with expertise in the field. Flares should be managed as in the non-pregnant population, while avoiding medications with unknown safety in pregnancy or known teratogens. Although commonly prescribed for the prevention of preeclampsia, there is limited evidence supporting the use of low-dose aspirin for pregnant women with vasculitis. Prospective registries or studies are needed, to better assess the value of aspirin, the place and long-term impact of new biologics and, to identify predictors of pregnancy outcomes other than disease status at conception.

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140. the Vasculitis Pregnancy Registry (Vpreg): Baseline Information for the First 3 Years

Cited by 2 publications

References 0 publications

Optimal management of ANCA-associated vasculitis before and during pregnancy: current perspectives

Optimal management of ANCA-associated vasculitis before and during pregnancy: current perspectives

Pregnancy Outcomes in Systemic Vasculitides

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