14-P019 Netrin1 in forebrain development

Abstract

Netrin1 is a member of a family of secreted molecules implicated in axon guidance, neuronal migration and apoptosis during development of central nervous system (CNS). Netrin1 signals in CNS through a group of transmembrane receptors belonging to the DCC (deleted in colorectal cancer) and C. elegans Unc5-related families. Netrin1 mutant mice die usually at birth with several CNS defects, but heterozygous mice are normal. We made Netrin1 expression analysis in developing and postnatal mouse brain.