14‐day famciclovir treatment significantly reduces the incidence of postherpetic neuralgia in elderly patients with herpes zoster

Kong, Jie; Wang, Huiping; Liu, Yuanjun; Xiao, Meng; Wang, Jing; Liu, Quanzhong

doi:10.1111/jcpt.13769

Cited by 2 publications

(2 citation statements)

References 20 publications

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“…Studies have shown that famciclovir can effectively reduce acute pain and the incidence of PHN. While not a standard treatment for PTSD + AUD, viral infections like HSV may contribute to neuroinflammation and worsen psychiatric symptoms( 128 ). Famciclovir could be considered as an adjunctive treatment to address viral factors and improve mental health in these patients.…”

Section: Discussionmentioning

confidence: 99%

Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models

Miranda,

Fan,

et al. 2023

Preprint

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Background Prediction of high-risk events in mental disorder patients is crucial. In our previous study, we developed a deep learning model: DeepBiomarker by using electronic medical records (EMR) to predict suicide related event (SRE) risk in post-traumatic stress disorder (PTSD) patients. Methods We applied DeepBiomarker2 through data integration of multimodal information: lab test, medication, co-morbidities, and social determinants of health. We analyzed EMRs of 5,565 patients from University of Pittsburgh Medical Center with a diagnosis of PTSD and alcohol use disorder (AUD) on risk of developing an adverse event (opioid use disorder, SREs, depression and death). Results DeepBiomarker2 predicted whether a PTSD + AUD patient will have a diagnosis of any adverse events (SREs, opioid use disorder, depression, death) within 3 months with area under the receiver operator curve (AUROC) of 0.94. We found piroxicam, vilazodone, dronabinol, tenofovir, suvorexant, empagliflozin, famciclovir, veramyst, amantadine, sulfasalazine, and lamivudine to have potential to reduce risk. Conclusions DeepBiomarker2 can predict multiple adverse event risk with high accuracy and identify potential risk and beneficial factors. Our results offer suggestions for personalized interventions in a variety of clinical and diverse populations.

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Section: Discussionmentioning

confidence: 99%

Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models

Miranda,

Fan,

et al. 2023

Preprint

View full text Add to dashboard Cite

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“…Regarding rst-line antiviral therapy, famciclovir was prescribed most frequently (37%), followed by valaciclovir (36%) and acyclovir (19%). When compared with traditional 7-day antiviral therapy, a 14-day course of famciclovir can reduce PHN in elderly patients with HZ [102].…”

Section: Preventionmentioning

confidence: 99%

An analysis and visualization of postherpetic neuralgia research between 1985 and 2022 using scientometrics

Cao

Zhang

et al. 2023

Preprint

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Background This study aimed to highlight the status of research on PHN between 1985 and 2022 through a bibliometric analysis and a historical review. Methods The Web of Science database was searched, and 3,386 relevant articles were included in the study. Bibliometric analysis was used to review the field distribution, regional distribution, and research topic evolution. Results Trends identified in the literature indicate that research on PHN is increasing globally. The United States is the leading country, and the University of California system is the leading institution in terms of publications. Glaxosmithkline had the highest number of citation bursts, indicating its important role in PHN research and drug development. PHN is primarily associated with older age and immunosuppression. Treatment mainly involves pharmacological, nonpharmacological, and interventional treatments, although data supporting the use of physical interventions are lacking. The main psychophysiological effects experienced by patients with PHN are anxiety, insomnia, and depression. Additionally, PHN results in a significant economic burden. Two vaccines have been approved for herpes zoster. Finally, animal models of PHN are inadequate. Conclusions The findings of this study provide valuable information for future research on PHN, e.g., research is needed on the mechanism of PHN, the development of suitable animal models, and the long-term effects of interventional treatment.

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14‐day famciclovir treatment significantly reduces the incidence of postherpetic neuralgia in elderly patients with herpes zoster

Cited by 2 publications

References 20 publications

Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models

Prediction of Adverse Events Risk in Patients with Comorbid Post- Traumatic Stress Disorder and Alcohol Use Disorder Using Electronic Medical Records by Deep Learning Models

An analysis and visualization of postherpetic neuralgia research between 1985 and 2022 using scientometrics

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