14-3-3zeta positive cells show more tumorigenic characters in human glioblastoma

14-3-3ζ negatively regulates mitochondrial biogenesis in GBM residual cells

“…Studies have also reported a strong association between 14-3-3ζ overexpression with glioma therapy resistance. For instance, Luo et al showed 14-3-3ζ positive cells having high cell viability, invasion, and resistance to temozolomide [19]. However, there is limited knowledge regarding the role of 14-3-3ζ in residual disease cell survival, especially that of GBM.…”