Abstract:Background
Retinoblastoma is a malignancy of the eye in children characterized by biallelic inactivation of
the retinoblastoma 1
gene (
RB1
), located at chromosome 13q14.2. Children with interstitial chromosome 13q deletions that include the
RB1
gene show a predisposition to develop retinoblastoma and variable other features. Large 13q deletions with severe clinical phenotype are nearly always the result of a de novo… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.