13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis

Leal, Yelda A.; Flores, Laura L; Fuentes‐Pananá, Ezequiel M.; Cedillo‐Rivera, Roberto; Torres, Javier

doi:10.1111/j.1523-5378.2011.00863.x

Cited by 93 publications

(109 citation statements)

References 72 publications

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“…In the current study 60 children aged 7-17 years were included which had difference compared to Kawakami et al (17) and Machado et al study (23) . In 2011, a systematic review and meta-analysis by Leal et al declared sensitivity of 95.9% and specificity 95.7% for all age groups (20) . The authors insisted that all results of UBT have to be adjusted for cutoff value, pretest meal, and urea dose.…”

Section: Discussionmentioning

confidence: 99%

“…The authors insisted that all results of UBT have to be adjusted for cutoff value, pretest meal, and urea dose. By accommodating these factors, the accuracy of the test can be improved (20) . UBT has a advantage over the endoscopy for evaluation of H. pylori, because it is non invasive and there is no sampling error associated with endoscopic biopsy because of patchy infiltration of H. pylori (24) .…”

Section: Discussionmentioning

confidence: 99%

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Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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-Background -Helicobacter pylori infection is the gram negative bacillus with the close association with chronic antral gastritis. Objective -In this study, we evaluate the accuracy of urea breath test (UBT) with carbon isotope 13 in comparison with histopathology of gastric antrum for detection of H. pylori infection in children with dyspepsia. Methods -This cross-sectional study was performed at specialized laboratory of Shiraz Gastroenterohepatology Research Center and Nemazee Hospital, Iran, during a 12-months period. This study investigated the sensitivity, specificity, and positive and negative predictive values of UBT in comparison with biopsy-based tests. We included a consecutive selection of 60 children who fulfilled Rome III criteria for dyspepsia. All children were referred for performing UBT with carbon isotope 13 (C13) as well as endoscopy. Biopsies were taken from antrum of stomach and duodenum. The pathologic diagnosis was considered as the standard test. Results -The mean age of the participants was 10.1±2.6 (range 7-17 years). From our total 60 patients, 28 (46.7%) had positive UBT results and 32 (53.3%) had negative UBT results. Pathologic report of 16 (57.1%) out of 28 patients who had positive UBT were positive for H. pylori and 12 (42.9%) ones were negative. Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Conclusion -Sensitivity and specificity of C13-UBT for detection of H. pylori infection were 76.2% and 69.2% respectively. Another multicenter study from our country is recommended. HEADINGS -Child health. Dyspepsia. Gastritis. Helicobacter infections. Peptic ulcer. Urease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Honar

Minazadeh

Shakibazad

et al. 2016

Arq. Gastroenterol.

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“…In addition, the urea breath test and the HpSA test are recommended for diagnosis in the guidelines regarding pediatric H. pylori infection [25]. Previously conducted studies reported that the urea breath test had a sensitivity and specificity in the range of 95.7–96.6 and 95.2–97.7%, respectively, and that the HpSA test had a sensitivity and specificity in the range of 88.9–96.0 and 94.0–96.8% respectively [23, 26-29]. The serologic test for H. pylori infection can be easily performed in epidemiologic studies using stored sera.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Latex Agglutination Turbidimetric Immunoassay in Screening Adolescents for Helicobacter pylori Infection in Japan

et al. 2018

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Background/Aims: Serologic tests are commonly used for screening Helicobacter pylori infection because they not only provide quick results but also are inexpensive. A new latex agglutination serum antibody assay (LZ test) has been developed and it is expected to be as effective as conventional assays. This study aimed to calculate a reliable cutoff value for the LZ test and to estimate the sensitivity and specificity of the cutoff value in screening adolescents for H. pylori infection in Japan. Methods: We screened junior high school students in Akita Prefecture, Japan, for H. pylori infection. We used the data of 213 such students who underwent H. pylori stool antigen (HpSA) tests in 2016. The students who had positive results with HpSA tests were diagnosed with H. pylori infection. Of the 213 students, 209 underwent the LZ test. Results: The prevalence rate of H. pylori infection was 3.8% (8/209). The area under the curve for the LZ test was 0.88. The cutoff value of the LZ test was determined to be 3.1 U/mL. At this value, the sensitivity and specificity were 87.5 and 91.5%, respectively. Conclusion: The accuracy of the LZ test in adolescents was well balanced for sensitivity and specificity as well as for tolerable results.

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“…In a meta-analysis, Leal et al [52] confirmed that the 13 C UBT is less accurate for the diagnosis of H. pylori infection in young children.…”

Section: Urea Breath Testmentioning

confidence: 99%

Epidemiology and Diagnosis of Helicobacter pylori Infection

et al. 2012

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Medline, PubMed and the Cochrane databases were searched on epidemiology and diagnosis of Helicobacter pylori for the period of April 2011-March 2012. Several studies have shown that the prevalence of H. pylori infection is decreasing in adults and children in many countries. Various diagnostic tests are available, and most of them have high sensitivity and specificity. The Maastricht IV/Florence consensus report states that the urea breath test using 13 C urea remains the best test to diagnose H. pylori infection. Among the stool antigen tests, the ELISA monoclonal antibody test is recommended. All these tests were used, either as a single diagnostic test or in combination, to investigate H. pylori infection among different populations throughout the world. Of particular interest, current improvements in high-resolution endoscopic technologies enable increased diagnostic accuracy for the detection of H. pylori infection, but none of these techniques, at present, are specific enough for obtaining a real-time diagnosis of H. pylori infection.

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13C-Urea Breath Test for the Diagnosis of Helicobacter pylori Infection in Children: A Systematic Review and Meta-Analysis

Cited by 93 publications

References 72 publications

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Diagnostic Accuracy of Urea Breath Test for Helicobacter Pylori Infection in Children With Dyspepsia in Comparison to Histopathology

Diagnostic Accuracy of Latex Agglutination Turbidimetric Immunoassay in Screening Adolescents for Helicobacter pylori Infection in Japan

Epidemiology and Diagnosis of Helicobacter pylori Infection

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