13C-selective infrared multiple photon dissociation of β-propiolactone by a free electron laser

Miyamoto, Yoshitomo; Majima, Tetsuro; Arai, Shigeyoshi; Katsumata, Keiichi; Akagi, Hiroshi; Maeda, Atsushi; Hata, Hiroo; Kuramochi, Kouji; Kato, Yuichi; Tsukiyama, Koichi

doi:10.1016/j.nimb.2010.10.026

Cited by 12 publications

(2 citation statements)

References 30 publications

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“…This characterization is based on matching measured vibrational frequencies of ions trapped in a mass spectrometer with reference spectra, either calculated or measured for model compounds. [1][2][3][4][5][6][7][8] Since infrared ion spectroscopy requires an intense and tunable infrared source, this technique has seen particularly widespread application at infrared free electron laser (FEL) facilities, 1,[9][10][11] but also tabletop sources such as optical parametric oscillators (OPOs) are in use in many labs.…”

Section: Introductionmentioning

confidence: 99%

Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer at the FELIX free electron laser laboratory

Martens

Berden

Gebhardt

et al. 2016

Review of Scientific Instruments

183

252

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We report on modifications made to a Paul-type quadrupole ion trap mass spectrometer and discuss its application in infrared ion spectroscopy experiments. Main modifications involve optical access to the trapped ions and hardware and software coupling to a variety of infrared laser sources at the FELIX infrared free electron laser laboratory. In comparison to previously described infrared ion spectroscopy experiments at the FELIX laboratory, we find significant improvements in efficiency and sensitivity. Effects of the trapping conditions of the ions on the IR multiple photon dissociation spectra are explored. Enhanced photo-dissociation is found at lower pressures in the ion trap. Spectra obtained under reduced pressure conditions are found to more closely mimic those obtained in the high-vacuum conditions of an Fourier transform ion cyclotron resonance mass spectrometer. A gas-mixing system is described enabling the controlled addition of a secondary gas into helium buffer gas flowing into the trap and allows for ion/molecule reactions in the trap. The electron transfer dissociation (ETD) option of the mass spectrometer allows for IR structure characterization of ETD-generated peptide dissociation products.

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Section: Introductionmentioning

confidence: 99%

Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer at the FELIX free electron laser laboratory

Martens

Berden

Gebhardt

et al. 2016

Review of Scientific Instruments

183

252

View full text Add to dashboard Cite

show abstract

“…I nfrared ion spectroscopy (IRIS), specifically infrared multiple photon dissociation (IRMPD) action spectroscopy, has become an important tool in the study of gas-phase ion structure in recent years [1][2][3][4]. The utility of this technique has historically been enabled only by intense, broadly-tunable free-electron lasers (FELs) present at just a few facilities across the globe [5][6][7][8]. Recently, table-top optical parametric oscillator laser (OPO) sources have become available that are able to provide complementary power to FELs in the hydrogenstretching region and thus enable more widespread accessibility to the infrared spectrum of gas-phase ions for IRMPD.…”

Section: Introductionmentioning

confidence: 99%

Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines

Hamlow

Zhu

Devereaux

et al. 2018

J. Am. Soc. Mass Spectrom.

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Modifications to a Paul-type quadrupole ion trap mass spectrometer providing optical access to the trapped ion cloud as well as hardware and software for coupling to a table-top IR optical parametric oscillator laser (OPO) are detailed. Critical experimental parameters for infrared multiple photon dissociation (IRMPD) on this instrument are characterized. IRMPD action spectra, collected in the hydrogen-stretching region with this instrument, complemented by spectra in the IR fingerprint region acquired at the FELIX facility, are employed to characterize the structures of the protonated forms of 2-thiouridine, [sUrd+H], and 4-thiouridine, [sUrd+H]. The measured spectra are compared with predicted linear IR spectra calculated at the B3LYP/6-311+G(d,p) level of theory to determine the conformers populated in the experiments. This comparison indicates that thiation at the 2- or 4-positions shifts the protonation preference between the 2,4-H tautomer and 4-protonation in opposite directions versus canonical uridine, which displays a roughly equal preference for the 2,4-H tautomer and O4 protonation. As found for canonical uridine, protonation leads to a mixture of conformers exhibiting C2'-endo and C3'-endo sugar puckering with an anti nucleobase orientation being populated for both 2- and 4-thiated uridine. Graphical Abstract ᅟ.

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Resonance laser-induced processes and energy transformations in adsorbed layers

Цыганенко

Kompaniets

Novikov

et al. 2019

Current Opinion in Chemical Engineering

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13C-selective infrared multiple photon dissociation of β-propiolactone by a free electron laser

Cited by 12 publications

References 30 publications

Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer at the FELIX free electron laser laboratory

Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer at the FELIX free electron laser laboratory

Modified Quadrupole Ion Trap Mass Spectrometer for Infrared Ion Spectroscopy: Application to Protonated Thiated Uridines

Resonance laser-induced processes and energy transformations in adsorbed layers

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