13C NMR spectroscopy as a tool for the in situ characterisation of iron-supplementing preparations

Kästele, Xaver; Sturm, Christine; Klüfers, Peter

doi:10.1016/j.ejpb.2013.11.003

Cited by 18 publications

(9 citation statements)

References 30 publications

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“…For sodium ferric gluconate, the absolute sucrose concentration is lower than in the iron sucrose preparation, but the amount compared to the iron content is similar and the pH is also lower. However, there is a compensatory factor due to the presence of gluconate, which forms a coordinative bond and even a chelate with the ferric oxyhydroxide [32]. Its chelation to iron can also drive the deprotonation of nearby hydroxyl groups, further enhancing the complex stability [33].…”

Section: The Carbohydrate Ligands Of the Iron-carbohydrate Preparatio...mentioning

confidence: 99%

Criticality of Surface Characteristics of Intravenous Iron–Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics

Funk

Flühmann

Barton

2022

IJMS

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Un-complexed polynuclear ferric oxyhydroxide cannot be administered safely or effectively to patients. When polynuclear iron cores are formed with carbohydrates of various structures, stable complexes with surface carbohydrates driven by multiple interacting sites and forces are formed. These complexes deliver iron in a usable form to the body while avoiding the serious adverse effects of un-complexed forms of iron, such as polynuclear ferric oxyhydroxide. The rate and extent of plasma clearance and tissue biodistribution is variable among the commercially available iron–carbohydrate complexes and is driven principally by the surface characteristics of the complexes which dictate macrophage opsonization. The surface chemistry differences between the iron–carbohydrate complexes results in significant differences in in vivo pharmacokinetic and pharmacodynamic profiles as well as adverse event profiles, demonstrating that the entire iron–carbohydrate complex furnishes the pharmacologic action for these complex products. Currently available physicochemical characterization methods have limitations in biorelevant matrices resulting in challenges in defining critical quality attributes for surface characteristics for this class of complex nanomedicines.

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Section: The Carbohydrate Ligands Of the Iron-carbohydrate Preparatio...mentioning

confidence: 99%

Criticality of Surface Characteristics of Intravenous Iron–Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics

Funk

Flühmann

Barton

2022

IJMS

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“…This is somewhat surprising because it has been shown that sucrose is not coordinated directly to Fe(III) centres in the colloidal preparations. 33 We suggest that the two significant voltammetric waves, obtained by a cathodic scan in alkaline Fe(III) solutions ( pH > 12) with chelators, or Fe(III) aggregated into clusters prior to dilution at lower pH, share the same origin. In some cases, the wave at more positive potential shows features that imply an origin from multiple but similar species.…”

Section: Discussionmentioning

confidence: 87%

Electrode reactions of iron oxide–hydroxide colloids

Mahmoudi

Kissner

2014

Dalton Trans.

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Small-sized FeO(OH) colloids stabilised by sugars, commercially available for the clinical treatment of iron deficiency, show two waves during cathodic polarographic sweeps, or two current maxima with stationary electrodes, in neutral to slightly alkaline aqueous medium. Similar signals are observed with Fe(III) in alkaline media, pH > 12, containing citrate in excess. Voltammetric and polarographic responses reveal a strong influence of fast adsorption processes on gold and mercury. Visible spontaneous accumulation was also observed on platinum. The voltammetric signal at more positive potential is caused by Fe(III)→Fe(II) reduction, while the one at more negative potential has previously been assigned to Fe(II)→Fe(0) reduction. However, the involvement of adsorption phenomena leads us to the conclusion that the second cathodic current is caused again by Fe(III)→Fe(II), of species deeper inside the particles than those causing the first wave. This is further supported by X-ray photoelectron spectra obtained after FeO(OH) particle adsorption and reduction on a gold electrode surface. The same analysis suggests that sucrose stabilising the colloid is still bound to the adsorbed material, despite dilution and rinsing.

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“…The exact mechanism of the co-catalyst effect is not apparent from the available data, however some recent studies have proposed chelation of Mn 2+ [33] and Fe 3+ [34] with carbohydrates in hydrolysis and dehydration reactions. Therefore the high co-catalytic activity of Mn 2+ , Fe 3+ , and Co 2+ observed in this study may be also due to a similar interaction or binding of the BAILmetal ion catalyst to cellulose surface, disrupting the cellulose Hbonding network.…”

Section: Resultsmentioning

confidence: 95%

1-(1-Propylsulfonic)-3-methylimidazolium chloride acidic ionic liquid catalyzed hydrolysis of cellulose in water: Effect of metal ion co-catalysts

Wiredu

Amarasekara

2015

Catalysis Communications

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The effect of eight metal ions, Cr 3+ , Mn 2+ , Fe 3+ , Co 2+ Ni 2+ , Cu 2+ , Zn 2+ and La 3+ on 1-(1-propylsulfonic)-3-methylimidazolium chloride acidic ionic liquid catalyzed hydrolysis of cellulose in water was studied at 140-170°C. Mn 2+ , Fe 3+ , and Co 2+ as co-catalysts produced significant enhancements in total reducing sugar (TRS) yields, with Mn 2+ showing the highest activity. Mn 2+ as co-catalyst produced 91.8, and 91.9% TRS yields, whereas samples without Mn 2+ gave 28.0 and 28.7% yields at 160 and 170°C respectively. The observed activation energies for cellulose hydrolysis without a co-catalyst and with Mn 2+ co-catalyst are 78.1 ± 1.4 and 32.8 ± 4.9 kJ·mol −1 respectively.

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13C NMR spectroscopy as a tool for the in situ characterisation of iron-supplementing preparations

Cited by 18 publications

References 30 publications

Criticality of Surface Characteristics of Intravenous Iron–Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics

Criticality of Surface Characteristics of Intravenous Iron–Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics

Electrode reactions of iron oxide–hydroxide colloids

1-(1-Propylsulfonic)-3-methylimidazolium chloride acidic ionic liquid catalyzed hydrolysis of cellulose in water: Effect of metal ion co-catalysts

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