Isotropic hyperfine coupling constants for 1H, 13C, 14N, 17O, and 19F nuclei in a large number of small radicals as obtained by the SCF-MO-LCAO-UHF-MINDO/3 scheme are presented. It is seen that whereas calculated 1H, 13C, and 14N hyperfine couplings agree fairly well with experiment, the agreement is not so satisfactory for 17O and 19F couplings.