13C-Angiography

Golman, Klaes; Ardenkjær-Larsen, Jan Henrik; Svensson, Jonas; Axelsson, Oskar; Hansson, Georg; Hansson, Lennart; Jóhannesson, Haukur; Leunbach, Ib; Månsson, Sven; Petersson, Johan; Pettersson, Göran; Servin, Rolf; Wistrand, Lars-Göran

doi:10.1016/s1076-6332(03)80278-7

Cited by 38 publications

(23 citation statements)

References 12 publications

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“…Most of the work to date has been with hyperpolarized noble gases such as 129 Xe and 3 He. However, recent developments have shown the feasibility of 13 C in a water-soluble form (42,55).…”

Section: Principles Of Mrimentioning

confidence: 99%

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Prasad

2006

American Journal of Physiology-Renal Physiology

106

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“…Most of the work to date has been with hyperpolarized noble gases such as 129 Xe and 3 He. However, recent developments have shown the feasibility of 13 C in a water-soluble form (42,55).…”

Section: Principles Of Mrimentioning

confidence: 99%

Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease

Prasad

2006

American Journal of Physiology-Renal Physiology

106

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“…We have previously presented two different techniques for hyperpolarizing 13 C in such molecules, and used them for imaging. These polarization techniques (parahydrogen-induced polarization (PHIP) (17), and dynamic nuclear polarization (DNP) (18)) differ from those used to hyperpolarize noble gases. The method used in the present work, DNP, was employed previously to improve the sensitivity of NMR in vitro (19) and to produce polarized targets in neutron-scattering experiments (20).…”

mentioning

confidence: 99%

Hyperpolarized ¹³C MR angiography using trueFISP

Svensson

Månsson

Johansson

et al. 2003

Magnetic Resonance in Med

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128

139

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A13 C-enriched water-soluble compound (bis-1,1-(hydroxymethyl)-1-13 C-cyclopropane-D 8 ), with a 13 C-concentration of approximately 200 mM, was hyperpolarized to ϳ15% using dynamic nuclear polarization, and then used as a contrast medium (CM) for contrast-enhanced magnetic resonance angiography (CE-MRA). The long relaxation times (in vitro: T 1 Ϸ 82 s, T 2 Ϸ 18 s; in vivo: T 1 Ϸ 38 s, T 2 Ϸ 1.3 s) are ideal for steady-state free precession (SSFP) imaging with a true fast imaging and steady precession (trueFISP) pulse sequence. It was shown both theoretically and experimentally that the optimal flip angle was 180°. CE-MRA was performed in four anesthetized live rats after intravenous injection of 3 ml CM. The angiograms covered the thoracic/abdominal region in two of the animals, and the head-neck region in the other two. Fifteen consecutive images were acquired in each experiment, with a flip-back pulse at the end of each image acquisition. In the angiograms, the vena cava (SNR Ϸ 240), aorta, renal arteries, carotid arteries (SNR Ϸ 75), jugular veins, and several other vessels were visible. The SNR in the cardiac region was 500. Magnetization was preserved from one image acquisition to the next using the flipback technique (SNR cardiac The most widespread technique for MR angiography (MRA) today utilizes an intravenous injection of a T 1 -shortening contrast medium (CM) in combination with T 1 -weighted pulse sequences (1,2). This contrast-enhanced (CE) MRA technique has substantially shorter imaging times than time-of-flight and phase-contrast methods, and is relatively insensitive to variations in blood flow velocity. Consequently, CE-MRA has increased the clinical impact of MRA. An interesting possibility for further elevation of the signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) in CE-MRA would be to use a hyperpolarized (HP) CM.It has been demonstrated that certain noble gases ( 3 He and 129 Xe) can be hyperpolarized to a much higher level (Ͼ10%) than that of thermal polarization of 1 H at clinical magnetic fields (ϳ0.0005%). This high degree of polarization compensates for the low spin density of the gases in vivo, and they (mostly 3 He) have been used to image airways and lungs (3-5). HP 3 He and 129 Xe have also been proposed for use in vascular imaging. Helium has low solubility in blood, but it can be delivered to the vascular system using encapsulation techniques (6 -9). Xenon, on the other hand, is directly soluble in blood, and inhalation of the gas is one way to administer HP xenon to the human vascular system (10 -12). Xenon can also be dissolved in a biocompatible carrier (13-16), to be delivered through intravenous injection. However, even if the hyperpolarized gases could be efficiently administered to the blood, the inherently low concentration of a gas makes 3 He and 129 Xe unsuitable as a CM for CE-MRA.A high vascular concentration of a hyperpolarized CM can be obtained if 13 C, as part of a water-soluble molecule, is polarized instead of 129 Xe and 3 He. We have previously...

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“…For both of these isotopes the potential signal enhancement due to high polarization was of limited benefit due to the low concentration of the tracer. Recently, the possibility of polarizing significant amounts of 13 C in labeled compounds has been demonstrated (20,21) using two separate techniques: dynamic nuclear polarization (DNP) (22) and parahydrogen-induced polarization (PHIP) (23), which result in substantially higher concentrations of the signal-generating nucleus than achieved with other polarization techniques (24). Specifically, the DNP technique can be used to polarize bis-1,1-(hydroxymethyl)-1-13 C-cyclopropane-D 8 , a water-soluble compound which exhibits a long 13 C relaxation time (T 1 equals 38 sec in vivo and 82 sec in vitro at 2.4 T (25)).…”

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confidence: 99%