138: Vitamin D Levels in Children With COVID-19 Admitted to the PICU

Nadiger, Meghana; Hassor, Sophia; Totapally, Balagangadhar

doi:10.1097/01.ccm.0000726440.30551.47

Cited by 2 publications

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“…This issue has made it important to pay attention to the effective roles of this vitamin in acute and chronic diseases. 8 In the present study, for the first time, the relationship between vitamin D and the severity of COVID-19 in children under 12 years of age was investigated. The findings of our study demonstrated that levels of this vitamin in individuals were related to tachycardia and tachypnea, gastrointestinal symptoms, and oxygen levels.…”

Section: Discussionmentioning

confidence: 93%

“…7 Low concentrations of vitamin D increase the risk of coronavirus disease in children. 8 Deficiency of this vitamin, by affecting liver function, increases the severity of coronavirus disease in people with risk factors such as obesity, diabetes, kidney and liver problems. Adequate levels of the vitamin can be suggested as a potential strategy for preventing and treating coronavirus disease.…”

Section: Ethical Publication Statementmentioning

confidence: 99%

“…Adequate levels of the vitamin can be suggested as a potential strategy for preventing and treating coronavirus disease. 8 , 9 Vitamin D is effective in decreasing the rate of microbial infections and mortality through various cellular mechanisms. This vitamin is also effective in decreasing the rate of common colds.…”

Section: Ethical Publication Statementmentioning

confidence: 99%

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Association of vitamin D and severity of COVID-19 in children

et al. 2022

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Vitamin has a major role in the functions of the immune system, and the efficacy of this vitamin in reducing inflammation has been identified. Considering the effects of vitamin D, this study research was performed for investigating the relationship between vitamin D and the severity of COVID-19 in children. This cross-sectional study was performed on 101 children infected with the new coronavirus from September 2020 to October 2021. Information on vitamin D levels, demographic factors, and clinical and laboratory findings were documented in information forms and prepared for statistical analyses. The average of children was 2.85 ± 0.85 years. Low oxygen saturation was observed in 35.3% of infected children. The level of involvement was higher in subjects with vitamin D levels higher than 30 and less than 10 ng/ml (p = 0.04). Clinical signs in cases with deficient and sufficient vitamin D levels were more severe in terms of tachypnea and tachycardia (p = 0.01). Children with vitamin D lower than 10 ng/ml showed more frequency (p = 0.02). Cases with moderate vitamin D had fewer gastrointestinal complications (p = 0.03). Also, oxygen levels were lower in children who had low levels of vitamin D (p = 0.02). Vitamin D levels were associated with levels of involvement, tachycardia, tachypnea, clinical signs, gastrointestinal problems, and O2 levels. Moderate vitamin D levels in children are a critical issue that should be considered.

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Section: Discussionmentioning

confidence: 93%

Section: Ethical Publication Statementmentioning

confidence: 99%

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Association of vitamin D and severity of COVID-19 in children

et al. 2022

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Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review

Shah

Varna

Pandya

et al. 2021

QJM: An International Journal of Medicine

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Aim We aim to study the relationship between vitamin D level, risk and severity of COVID-19 infection in pediatric population through systematic review. Methods We searched PubMed, CINAHL, EMBASE, Cochrane Library and Google Scholar from December 2019 to June 2021 for retrieving articles studying association between vitamin D deficiency with COVID-19. Qualitative details were synthesized in evidence table and quantitative data was used for deriving pooled estimate through meta-analysis. Results After initial search of 2261 articles, eight eligible studies (two reviews) were included in the systematic review. Meta-analysis of the quantitative data (six studies) showed pooled prevalence of vitamin D deficiency as 45.91% (95% CI : 25.148-67.450). In infected pediatric patients, low levels of vitamin D increased the risk of severe disease (odds ratio - 5.5; 95% CI : 1.560- 19.515; p = 0.008). It was also found that children and adolescents having vitamin D deficiency had greater risk of COVID infection as compared to patients with normal vitamin D levels. Improvement in disease severity with vitamin D supplementation was also noted. Conclusion The systematic review showed that almost half of the pediatric COVID patients suffer from vitamin D deficiency. It is also clear that the low level of vitamin D is associated with greater risk of infection and poorer outcome in pediatrics.

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138: Vitamin D Levels in Children With COVID-19 Admitted to the PICU

Cited by 2 publications

References 0 publications

Association of vitamin D and severity of COVID-19 in children

Association of vitamin D and severity of COVID-19 in children

Low vitamin D levels and prognosis in a COVID-19 pediatric population: a systematic review

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