(137) Meningeal application of prolactin and CGRP produces female specific migraine-related behavior in rodents

Vega, Christopher; Quigley, Lilyana; Patel, Mansi; Price, Theodore J.; Arkopian, A.; Dussor, Gregory

doi:10.1016/j.jpain.2017.02.043

Cited by 4 publications

(4 citation statements)

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Section: Discussionsupporting

confidence: 89%

“…Although studies evaluating prolactin levels in subjects with migraines have shown different results, taken as a whole, our results on the levels of prolactin in migraineurs compared to controls appear to be corroborated by previous evidence in this field (Cavestro et al, 2006;Li et al, 2018;Nattero et al, 1986;Taha & Mohammed, 2019;Vega et al, 2017). Li et al (2018) assessed serum different hormones related to female gonadal function including prolactin of migraineurs and analyzed the relationship between these hormone levels and migraine characteristics.…”

Section: Discussionsupporting

confidence: 83%

“…It is worth mentioning that most previous studies only evaluated the difference of prolactin level among migraineurs and a headache‐free control group (Cavestro et al., 2006 ; Guldiken et al., 2011 ; Li et al., 2018 ; Masoud & Fakharian, 2005 ; Seddighi & Dehghani, 2002 ; Taha & Mohammed, 2019 ; Vega et al., 2017 ), while in our study, we compared prolactin levels in patients with chronic migraine, episodic migraine in ictal and interictal phases and control subjects separately. In addition to, the correlation between prolactin levels and the number of headache days was assessed in our study.…”

Section: Discussionmentioning

confidence: 99%

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Increased serum prolactin level may indicate more migraine attack frequency

et al. 2023

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Objectives Migraine is a common, multifactorial disorder. The exact pathomechanism of migraine remains unclear. Studies have revealed changes in serum prolactin (PRL) levels in relation to migraine, although the results have been inconsistent. The present case‐control study assessed the serum level of prolactin in migraine patients. Materials and methods In this case‐control study, participants were divided into chronic migraine (CM; n = 39), episodic migraine in ictal (during an attack), and interictal (between attacks) phases (n = 63, n = 37, respectively) along with 30 age‐ and sex‐matched headache‐free controls. After obtaining demographic, anthropometric data, and headache characteristics, blood samples were gathered and analyzed to evaluate the serum levels of prolactin (ng/mL). Results A significant difference was observed between the control, CM, and ictal EM, and interictal EM groups. The mean ± SD serum prolactin levels of the chronic migraineurs (1.82 ± 0.94) and those with ictal EM (1.93 ± 1.70) were comparable and were significantly higher than for interictal EM patients (0.82 ± 0.46) and the headache‐free control subjects (0.49 ± 0.15; p < .001). Although the mean serum concentration of prolactin for the interictal EM group tended to be higher than for control individuals, this difference was not statistically significant. The Spearman's correlation test also showed significant correlations between the serum prolactin levels and the number of headaches days among migraineurs. Conclusion The findings suggest that there might be an association between increased prolactin concentrations and migraine headache induction and progression. Further detailed and well‐designed studies are needed to confirm the importance of serum prolactin levels in the pathogenesis of migraine headaches.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 99%

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Increased serum prolactin level may indicate more migraine attack frequency

et al. 2023

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“…Women are more likely to have allodynia than men in this and in other studies. One explanation for this may be the recent finding that prolactin, which potentiates the release of calcitonin gene related peptide in female animals but not males, also sensitizes dural nociceptors in female but not male animals (32). The fact that prolactin receptors are expressed in dural sensory nerve fibers exclusively in female animals may in part explain the sex-specific differences in migraine prevalence in general, as well as the propensity for women to be more at risk of sensitization and allodynia.…”

Section: Discussionmentioning

confidence: 99%

Predictors of allodynia in persons with migraine: Results from the Migraine in America Symptoms and Treatment (MAST) study

Dodick

Reed²,

Fanning³

et al. 2019

Cephalalgia

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Background Cutaneous allodynia is a common clinical feature of migraine that has been associated with reduced efficacy of acute migraine treatments and an increased risk of disease progression. Objective Identify factors associated with allodynia in a sample of adults with migraine. Methods An online survey panel was used to identify adults with migraine who averaged at least 1 monthly headache day over the previous 3 months. Data on sociodemographics, headache frequency, headache pain intensity, migraine symptom severity, medication use, depression and anxiety, and cutaneous allodynia (via the Allodynia Symptom Checklist) were obtained. Binary logistic modeling predicted the presence of allodynia. Odds ratios and 95% confidence intervals (CI) were calculated. Results In total, 15,133 individuals with migraine met the eligibility criteria. Mean age was 43.1 years, 73.0% were female, and 81.0% were Caucasian. Allodynia was present in 39.9%. The fully adjusted model, controlling for sociodemographics and headache features, demonstrated that allodynia was significantly associated with a higher migraine symptom severity score (odds ratio 1.17, confidence interval 1.15, 1.19) and more severe pain intensity (odds ratio 1.11, confidence interval 1.08, 1.14); probable depression and/or anxiety (odds ratio 1.83, confidence interval 1.67, 2.00); and overuse of acute medication (odds ratio 1.23, confidence interval 1.09, 1.38). A higher number of monthly headache days increased the likelihood of allodynia, but the effect was attenuated in the fully adjusted model. Conclusion In a representative sample of US adults with migraine, there were significant associations between allodynia and headache frequency and intensity, anxiety and/or depression, symptom severity, and acute medication overuse.

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CGRP in Animal Models of Migraine

Wattiez

Wang

Russo

2018

Calcitonin Gene-Related Peptide (CGRP) Mechanisms

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With the approval of calcitonin gene-related peptide (CGRP) and CGRP receptor monoclonal antibodies by the Federal Drug Administration, a new era in the treatment of migraine patients is beginning. However, there are still many unknowns in terms of CGRP mechanisms of action that need to be elucidated to allow new advances in migraine therapies. CGRP has been studied both clinically and preclinically since its discovery. Here we review some of the preclinical data regarding CGRP in animal models of migraine.

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(137) Meningeal application of prolactin and CGRP produces female specific migraine-related behavior in rodents

Cited by 4 publications

References 0 publications

Increased serum prolactin level may indicate more migraine attack frequency

Increased serum prolactin level may indicate more migraine attack frequency

Predictors of allodynia in persons with migraine: Results from the Migraine in America Symptoms and Treatment (MAST) study

CGRP in Animal Models of Migraine

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