137 Concordance between intravenous antibiotics (IV) and in vitro susceptibility of sputum bacteria does not influence the outcome of pulmonary exacerbations in adult cystic fibrosis patients

Extending the course of intravenous antibiotics in adult patients with cystic fibrosis with acute pulmonary exacerbations

“…This is not withstanding the previous studies, which showed that there was no difference in the outcome of treating exacerbations when there was or was not a synchronisation between the prescribed antibiotics and in vitro sensitivity profile. 27,28 In the CF community, there is an emphasis on introducing much needed new therapeutic agents acting on several aspects of the CF syndrome. This includes testing new antimicrobial agents, anti-inflammatory treatments and mucolytic agents.…”

“…This is not withstanding the previous studies, which showed that there was no difference in the outcome of treating exacerbations when there was or was not a synchronisation between the prescribed antibiotics and in vitro sensitivity profile. 27,28…”

Cystic Fibrosis Pulmonary Exacerbation – Natural History, Causative Factors and Management

“…Previous in vitro sensitivity and previous clinical response normally determine the choice of antibiotics. However, several retrospective and prospective studies found that the concordance of in vitro sensitivity did not affect any of the outcomes of the CF exacerbations, including lung function tests and the time until the subsequent pulmonary exacerbation (Jarad et al, 2007;Foweraker et al, 2005).…”