Abstract:Polycomb repressive complexes (PRCs) are essential chromatin regulators of cell identity. PRC1, which is a dominant executer of Polycomb-mediated control, possesses catalyticdependent H2AK119 mono-ubiquitination and catalytic-independent activities. Despite extensive knowledge of PRC1s role in embryonic stem cells (SCs), its function in somatic SCs and tissue development is largely unknown. Here, we show that despite its well-established repressor functions, PRC1 binds to both silent and active genes in epider… Show more
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