1352. A Computational Approach for Exploring the Binding Mechanism of Chebulinic Acid on Herpes Simplex Virus-2 and Its Implication on Chikungunya and Dengue
Abstract:BackgroundChebulinic acid (CA), a natural compound isolated from the tree Terminalia chebula, was recently reported to have shown antiviral activity against Herpes simplex virus-2 (HSV-2). The study showed inhibition activity of CA, preventing the attachment of HSV-2 on the host cells. This activity was speculated to be due to an interaction between CA and viral surface glycoproteins, triggering alterations in its function or making virus particles inert and preventing their attachment to host cells. However, … Show more
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