1346Laser doppler assessment of dermal microcirculatory endothelial function in patients with angina and non-obstructive coronary arteries

Sheikh, A.; DiFiore, David; Rajendran, S; Zeitz, Christopher; Beltrame, John F.

doi:10.1093/eurheartj/ehy565.1346

Cited by 2 publications

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“…При оценке состояния МЦР кожи пальца с применением КВК у пациентов с ГКМП нами впервые обнаружено статистически значимое снижение показателей, отображающих структурно-функциональные изменения. Примечательно, что в ряде исследований различных ССЗ оценка периферического МЦР отражает изменения, происходящие в микроциркуляции коронарного русла [19,20]. Кроме того, оценка капиллярного русла ногтевого ложа с применением КВК у пациентов с системной склеродермией достоверно ассоциирована с коронарной микроваскулярной дисфункцией, выявленной во время трансторакальной ЭхоКГ в виде снижения коронарного резерва перфузии [21].…”

Section: Discussionunclassified

Assessment of the structural and functional state of blood vessels in patients with hypertrophic cardiomyopathy

et al. 2021

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Aim To evaluate the structural and functional condition of the vasculature using fingertip photoplethysmography and computerized videocapillaroscopy in patients with hypertrophic cardiomyopathy (HCMP).Material and methods The study included patients with HCMP (n=48; 28 (57 %) men; age, 54.3±13.6 years) and healthy volunteers (control group, n=33, 15 (45 %) men; age, 58.2±8.8 years). Standard laboratory and instrumental examination (blood count and biochemistry, electrocardiography, echocardiography, Holter electrocardiogram monitoring) were performed for all HCMP patients. The condition of vascular wall at various levels of the vasculature was evaluated by fingertip photoplethysmography (apparatus Angioscan-01) and computerized nail-fold videocapillaroscopy (apparatus Capillaroscan-01). The photoplethysmography study analyzed structural parameters, including the arterial wall stiffness index (aSI) of large blood vessels and the resistance index (RI) of small muscular arteries. Endothelial dysfunction was evaluated by the occlusion index (OI) and phase shift (PS). The capillaroscopy study assessed structural parameters, including the resting capillary density (rCD) and the capillary density following venous occlusion (voCD), and functional parameters, including the percentage of perfused capillaries (PPC), the percentage of restored capillaries (PRC), and the capillary density after the reactive hyperemia test (rhCD).Results The study showed increases in aSI (8.8 [6.8; 12.2] and RI (32.5 [17.4; 47.9] in the HCMP group. The OI was significantly lower in the HCMP group (1.3 [1.1; 1.5]) than in the control group (1.8 [1.5; 2.7], р<0.001). Also, PS values were significantly decreased in the HCMP group (4.4 [2.3; 8.6]) compared to the control group (8.4 [5.1; 12.1]. p=0.018). Disorders of structural and functional capillary indexes were observed in HCMP patients compared to the control group; rCD and voCD were decreased in the HCMP group (60 [52.6; 68] and 88 [75; 90], respectively) compared to the control group (75.8 [60; 87] and 90 [73; 101]), however, no intergroup difference reached a statistical significance. The rhCD, PPC, and PRC values were decreased in the HCMP group (66.3 [55; 72], 86.7 [70.9; 104.2] and 1.7 [–6.95; 20.3], respectively) compared to the control group (86 [68.6; 100], 103 [96; 114] and 18.4 [8.1; 27.4], respectively); PPC and PRC values were significantly different (р<0.005 and p<0.004, respectively).Conclusion In patients with HCMP, fingertip photoplethysmography and computerized videocapillaroscopy showed increased wall stiffness in both large blood vessels and microvasculature, pronounced endothelial dysfunction, and decreases in capillary density and percentage of restored capillaries following respective tests.

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Section: Discussionunclassified

Assessment of the structural and functional state of blood vessels in patients with hypertrophic cardiomyopathy

et al. 2021

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“…Microvascular dilation in response to Ach, local heating and cuff occlusion are all diminished in people with known CAD 37 . Using LDF, Sheikh et al showed in patients presenting with angina that epicardial artery endothelial dysfunction positively correlated with decreased dermal microvascular reactivity to Ach, suggesting that the changes in the peripheral microcirculation may offer clues regarding the health of our coronary system 92 . A summary of the methods and techniques in which to assess the microvasculature are presented in Table 1.…”

Section: Inside‐out and Outside‐in: Assessment Of Human Coronary Micrmentioning

confidence: 99%

Sweat the small stuff: The human microvasculature and heart disease

et al. 2020

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Traditionally thought of primarily as the predominant regulator of myocardial perfusion, it is becoming more accepted that the human coronary microvasculature also exerts a more direct influence on the surrounding myocardium. Coronary microvascular dysfunction (CMD) not only precedes large artery atherosclerosis, but is associated with other cardiovascular diseases such as heart failure with preserved ejection fraction and hypertrophic cardiomyopathy. It is also highly predictive of cardiovascular events in patients with or without atherosclerotic cardiovascular disease.This review focuses on this recent paradigm shift and delves into the clinical consequences of CMD. Concepts of how resistance arterioles contribute to disease will be discussed, highlighting how the microvasculature may serve as a potential target for novel therapies and interventions. Finally, both invasive and non-invasive methods with which to assess the coronary microvasculature both for diagnostic and risk stratification purposes will be reviewed.

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1346Laser doppler assessment of dermal microcirculatory endothelial function in patients with angina and non-obstructive coronary arteries

Cited by 2 publications

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Assessment of the structural and functional state of blood vessels in patients with hypertrophic cardiomyopathy

Assessment of the structural and functional state of blood vessels in patients with hypertrophic cardiomyopathy

Sweat the small stuff: The human microvasculature and heart disease

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