134 UVR-induced decrease of epidermal proliferation/differentiation is differently inhibited by melatonin and its metabolites AFMK and AMK

Ameliorative role of melatonin against cypermethrin or gamma irradiation induced testicular damage in male rats

“…These findings are consistent with the findings of previous studies (40,41) .Besides MLT capability to scavenge hydroxyl radical (17) , also it possesses effective detoxifying capacity to further ROS and reactive nitrogen species in addition to their metabolites, peroxynitrous acid, and intermediates H2O2 (47) . Furthermore, MLT upregulate numerous antioxidant enzymes, thus boosts the antioxidant potential of the cell (48,49) . Since it was shown to stimulate the synthesis of the rate-limiting enzyme, γ-glutamylcysteine synthase, which inhibits the pero-oxidative enzymes nitric oxide synthase and lipoxygenase (50) , MLT determines the total amount of cellular GSH due to its crucial role in maintaining GSH homeostasis within the cell.…”