1321 Endocannabinoid-like molecule oleoylethanolamide promotes sebaceous lipid synthesis

Tóth, Kinga Fanni; Markovics, Arnold; Angyal,; Magi, József; Kovács, Ilona; Zouboulis, C. C.; Bı́ró, Tamás; Oláh, Attila

doi:10.1016/j.jid.2018.03.1338

Cited by 1 publication

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“…Moreover, the expression of an important cellular target of the latter, namely GPR119, was also identified on human sebocytes. The available scarce evidence suggests that the OEA→GPR119→ERK1/2 MAPK signaling chain may be a previously unknown promoter of sebocyte differentiation, and therefore dysregulation of this pathway may contribute to the development of seborrhea and acne [ 116 ]. This seems to be particularly interesting, since GPR119 has recently emerged as a promising therapeutic target in type 2 diabetes mellitus.…”

Section: Translational Potential Of the Cutaneous Cannabinoid Signmentioning

confidence: 99%

“…This seems to be particularly interesting, since GPR119 has recently emerged as a promising therapeutic target in type 2 diabetes mellitus. Although the tested synthetic agonists have not passed yet phase II clinical trials [ 117 ], and both endogenous and synthetic agonists of GPR119 may exhibit biologically relevant signaling bias [ 73 ], these preliminary findings warn of the risk of unexpected cutaneous side effects upon administration of GPR119 activators exhibiting “OEA-like” signaling preference [ 116 ].…”

Section: Translational Potential Of the Cutaneous Cannabinoid Signmentioning

confidence: 99%

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Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

et al. 2019

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The endocannabinoid system (ECS) has lately been proven to be an important, multifaceted homeostatic regulator, which influences a wide-variety of physiological processes all over the body. Its members, the endocannabinoids (eCBs; e.g., anandamide), the eCB-responsive receptors (e.g., CB1, CB2), as well as the complex enzyme and transporter apparatus involved in the metabolism of the ligands were shown to be expressed in several tissues, including the skin. Although the best studied functions over the ECS are related to the central nervous system and to immune processes, experimental efforts over the last two decades have unambiguously confirmed that cutaneous cannabinoid (“c[ut]annabinoid”) signaling is deeply involved in the maintenance of skin homeostasis, barrier formation and regeneration, and its dysregulation was implicated to contribute to several highly prevalent diseases and disorders, e.g., atopic dermatitis, psoriasis, scleroderma, acne, hair growth and pigmentation disorders, keratin diseases, various tumors, and itch. The current review aims to give an overview of the available skin-relevant endo- and phytocannabinoid literature with a special emphasis on the putative translational potential, and to highlight promising future research directions as well as existing challenges.

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Section: Translational Potential Of the Cutaneous Cannabinoid Signmentioning

confidence: 99%

Section: Translational Potential Of the Cutaneous Cannabinoid Signmentioning

confidence: 99%

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

et al. 2019

View full text Add to dashboard Cite

show abstract

1321 Endocannabinoid-like molecule oleoylethanolamide promotes sebaceous lipid synthesis

Cited by 1 publication

References 0 publications

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

Cannabinoid Signaling in the Skin: Therapeutic Potential of the “C(ut)annabinoid” System

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