13 Immunological Evaluation of a Tissue Sealant Used in Laparoscopic Porcine Partial Nephrectomy

Synthesis and Antioxidant Activity of Amido‐Linked Benzoxazolyl/Benzothiazolyl/Benzimidazolyl‐Pyrazoles and Isoxazoles

“…In general, amido-linked benzoxazolyl pyrazoles (14) and isoxazoles (17) displayed higher radical scavenging activity than benzothiazolyl pyrazoles (15) and isoxazoles (18), benzimidazolyl pyrazoles (16) and isoxazoles (19). Further, it was observed that the compounds with benzothiazolyl moiety (15, 18) exhibited greater activity than those with benzimidazolyl moiety (16,19). It was also observed that compounds having methyl substituent on the phenyl ring displayed significant activity than unsubstituted and chlorosubstituted ones.…”

“…Concentration (μg/mL) 50 75 100 (14)(15)(16)(17)(18)(19) exhibited greater activity than the corresponding non-aromatized compounds (8)(9)(10)(11)(12)(13).…”

“…Pyrazoles show pronounced pharmacological applications as antianxiety [8], antidiabetic [9], antimicrobial [10,11], herbicidal [12] and anti-inflammatory [13]. Isoxazoles exhibit analgesic [14], anti-inflammatory [14], ulcerogenic [14], antimicrobial [15], antifungal [15], COX-2 inhibitory [16,17] and anticancer [18] activities. Amongst different methods for the preparation of pyrazolines and isoxazolines, the 1,3-dipolar cycloaddition is the most important and versatile one.…”