13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT1AReceptor, and Serotonin Reuptake Transporter LevelsIn Vitro

O’Reilly, Kally C.; Trent, Simon; Bailey, Sarah; Lane, Michelle A.

doi:10.3181/0703-rm-83

Cited by 54 publications

(53 citation statements)

References 51 publications

(68 reference statements)

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“…Our finding of higher 5-HT 1A in NRM MDD is replicable and also consistent with post-mortem data [26], as well as data from other modalities [29,37,41]. Furthermore, it lends additional support to the hypothesis of higher 5-HT 1A in depression and agrees with the purported model underlying selective serotonin reuptake inhibitors (SSRIs) [42,43].…”

Section: Future Directions and Implicationssupporting

confidence: 88%

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression

Hesselgrave¹,

Parsey

2013

Phil. Trans. R. Soc. B

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One contribution of 11 to a Theme Issue 'The neurobiology of depression-revisiting the serotonin hypothesis. II. Genetic, epigenetic and clinical studies'. ography, we have studied the 5-HT 1A receptor, first in a group of healthy controls, then in two separate groups of subjects with major depressive disorder (MDD) (antidepressant exposed and not recently medicated), and, lastly, in a group of subjects remitted from MDD. All MDD subjects were medication-free at the time of scan. We found higher 5-HT 1A binding potential (BP F ) in MDD subjects not recently exposed to an antidepressant compared with controls and recently medicated MDD subjects; and higher BP F in subjects with the C(-1019)G promoter polymorphism. We replicated these findings in a novel cohort and reconciled our discrepant findings with other groups using alternate quantification techniques. We also reported higher BP F in subjects remitted from a major depressive episode than in controls. From this work, we proposed a temporal model in which 5-HT 1A BP F may be a trait abnormality of MDD. To further explore the genetic components of MDD and utility of 5-HT 1A imaging as a potential tool for biomarker or treatment response prediction, these findings should be replicated in a larger cohort using the [ 11 C]CUMI-101 agonist tracer.

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Section: Future Directions and Implicationssupporting

confidence: 88%

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression

Hesselgrave¹,

Parsey

2013

Phil. Trans. R. Soc. B

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“…This indicates that they Several studies have shown that the molecular components needed for retinoic acid signalling are expressed in the adult brain, suggesting that retinoids could play a role in affective disorders. [21][22][23][24][25][26][27][28][29] In young adult mice, chronic administration of isotretinoin induced depression related behaviours. 22 These changes were not seen in adult rats.…”

Section: Discussionmentioning

confidence: 99%

Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study

Sundström

Alfredsson

Sjölin‐Forsberg

et al. 2010

BMJ

165

126

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An increased risk of attempted suicide was apparent up to six months after the end of treatment with isotretinoin, which motivates a close monitoring of patients for suicidal behaviour for up to a year after treatment has ended. However, the risk of attempted suicide was already rising before treatment, so an additional risk due to the isotretinoin treatment cannot be established. As patients with a history of suicide attempts before treatment made new attempts to a lesser extent than did patients who started such behaviour in connection with treatment, patients with severe acne should not automatically have isotretinoin treatment withheld because of a history of attempted suicide.

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“…However, high doses of retinoic acid are currently being used for the prevention and treatment of certain cancers and skin diseases (Germain et al, 2006). Because such doses may have side-effects on brain function (O'Reilly et al, 2007;Bremner and McCaffery, 2008), it will be of interest to investigate further their effects in the adult brain.…”

Section: Discussionmentioning

confidence: 99%

Dietary retinoic acid affects song maturation and gene expression in the song system of the zebra finch

Wood

Olson

Lovell

et al. 2008

Developmental Neurobiology

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Vitamin A, an essential nutrient, is required in its acidic form (retinoic acid) for normal embryogenesis and neuronal development, typically within well-defined concentration ranges. In zebra finches, a songbird species, localized retinoic acid synthesis in the brain is important for the development of song, a learned behavior sharing significant commonalities with speech acquisition in humans. We tested how dietary retinoic acid affects the development of song behavior and the brain's system for song control. Supplemental doses of retinoic acid given to juveniles during the critical period for song learning resulted in more variable or plastic-like songs when the birds reached adulthood, compared to the normal songs of vehicle-fed controls. We also observed that several genes (brinp1, nrgn, rxr-alpha, and sdr2/scdr9) had altered levels of expression in specific nuclei of the song system when comparing the experimental and control diet groups. Interestingly, we found significant correlations between gene expression levels in nuclei of the anterior forebrain pathway (lMAN and area X) and the degree of variability in the recorded songs. We observed, however, no major morphological effects such as changes in the volumes of song nuclei. Overall, our results lend further support to a fundamental role of retinoic acid in song maturation and point to possible molecular pathways associated with this action. The data also demonstrate that dietary content of Vitamin A can affect the maturation of a naturally learned complex behavior.

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13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT_1AReceptor, and Serotonin Reuptake Transporter LevelsIn Vitro

Cited by 54 publications

References 51 publications

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression

Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study

Dietary retinoic acid affects song maturation and gene expression in the song system of the zebra finch

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13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT1AReceptor, and Serotonin Reuptake Transporter LevelsIn Vitro

Cited by 54 publications

References 51 publications

Imaging the serotonin 1A receptor using [ 11 C]WAY100635 in healthy controls and major depression

Imaging the serotonin 1A receptor using [ 11 C]WAY100635 in healthy controls and major depression

Association of suicide attempts with acne and treatment with isotretinoin: retrospective Swedish cohort study

Dietary retinoic acid affects song maturation and gene expression in the song system of the zebra finch

Contact Info

Product

Resources

About

13-cis-Retinoic Acid Alters Intracellular Serotonin, Increases 5-HT_1AReceptor, and Serotonin Reuptake Transporter LevelsIn Vitro

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression

Imaging the serotonin 1A receptor using [ ¹¹ C]WAY100635 in healthy controls and major depression