1995
DOI: 10.1016/s0091-6749(95)70030-7
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13-Hydroxy-linoleic acid induces airway hyperresponsiveness to histamine and methacholine in guinea pigs in vivo

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Cited by 13 publications
(10 citation statements)
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“…Similarly dysfunctional mitochondria have been found in human asthmatic bronchial epithelia30. Transfer of mitochondria from stem cells to alveolar epithelial cells reversed acute lung injury in sepsis, indicating the crucial role that mitochondrial health in lung diseases17. In this context, understanding the effects of 13-S-HODE on airway epithelium is essential because we found its levels to be high in the airway secretions and extracellular fluids.…”
Section: Discussionsupporting
confidence: 62%
See 1 more Smart Citation
“…Similarly dysfunctional mitochondria have been found in human asthmatic bronchial epithelia30. Transfer of mitochondria from stem cells to alveolar epithelial cells reversed acute lung injury in sepsis, indicating the crucial role that mitochondrial health in lung diseases17. In this context, understanding the effects of 13-S-HODE on airway epithelium is essential because we found its levels to be high in the airway secretions and extracellular fluids.…”
Section: Discussionsupporting
confidence: 62%
“…13-S-hydroxyoctadecadienoic acid (13-S-HODE) is a lipid metabolite derived from linoleic acid, a major polyunsaturated fatty acid, through various enzymatic sources like 15-lipoxygenase, cyclooxygenase and nonenzymatic mechanisms like auto-oxidation131415. 13-S-HODE is produced in large quantities during mitochondrial degradation steps in RBC maturation16 whereas 13-hydroxy-linoleic acid, a related molecule, has been linked to airway hyperresponsiveness17. We studied 13-S-HODE as a potential link between mitochondrial dysfunction, epithelial injury, and airway disease because of increasing evidence of the role of mitochondrial dysfunction789.…”
mentioning
confidence: 99%
“…Among the significantly altered 15-LOX products, 13-HODE is the most well studied LA derivative and of demonstrated importance in airway disease [33], [37]. 13-HODE has been shown to alter the activity of the anti-inflammatory receptor PPARγ in a concentration dependent manner [33], [38], [39].…”
Section: Discussionmentioning
confidence: 99%
“…In other words, exogenous PPAR␥ agonists in therapeutic concentrations might act as a negative immunomodulator, whereas endogenous or natural ligands in physiological concentrations might have some proinflammatory effects. It is also worth noting that naturally occurring fatty acid-derived molecules, such as 13-hydroxyoctadecadienoic acid and 15-hydroxyeicosatetraenoic acid, which are also known as ligands of PPAR␥, contribute to the pathophysiology of allergic airway inflammation (38,39). Thus, additional studies are necessary to clarify the physiological role of PPAR␥.…”
mentioning
confidence: 99%