13. Event-related potentials (N 400) in autistic children

Mendez, Mario F.; Sans, Oscar; Abril, Beatriz; Valdizán, J R

doi:10.1016/j.clinph.2008.09.041

Cited by 7 publications

(8 citation statements)

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“…Within the full ASD group, there was substantial heterogeneity in performance, both in terms of behavioral assessments of language, and ERP variables. Our findings are somewhat inconsistent with research demonstrating an absent N400 in children with ASD (Cantiani et al, 2016; Dunn and Bates, 2005; McCleery et al, 2010), although other studies have found intact N400 effects (Coderre, 2017; Fishman et al, 2011; Méndez et al, 2009). The inconsistent findings across studies seem likely due to the variability across children with ASD, combined with relatively small sample sizes.…”

Section: Discussioncontrasting

confidence: 99%

“…These studies have yielded mixed findings, some showing reduced or absent N400 responses in individuals with ASD, while others have found an intact N400 response or other ERP response. Relatively intact N400 effects have been demonstrated in adults with ASD, using a sentence congruence paradigm (Fishman et al, 2011), as well as in children (Méndez et al, 2009) and adults (Coderre, 2017) in the context of single-word priming paradigms.…”

Section: Introductionmentioning

confidence: 99%

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ERP evidence of semantic processing in children with ASD

DiStefano

Şentürk

Jeste

2019

Developmental Cognitive Neuroscience

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25% of children with autism spectrum disorder (ASD) remain minimally verbal (MV), despite intervention. Electroencephalography can reveal neural mechanisms underlying language impairment in ASD, potentially improving our ability to predict language outcomes and target interventions. Verbal (V) and MV children with ASD, along with an age-matched typically developing (TD) group participated in a semantic congruence ERP paradigm, during which pictures were displayed followed by the expected or unexpected word.An N400 effect was evident in all groups, with a shorter latency in the TD group. A late negative component (LNC) also differentiated conditions, with a group by condition by region interaction. Post hoc analyses revealed that the LNC was present across multiple regions in the TD group, in the mid-frontal region in MVASD, and not present in the VASD group. Cluster analysis identified subgroups within the ASD participants. Two subgroups showed markedly atypical patterns of processing, one with reversed but robust differentiation of conditions, and the other with initially reversed followed by typical differentiation. Findings indicate that children with ASD, including those with minimal language, showed EEG evidence of semantic processing, but it was characterized by delayed speed of processing and limited integration with mental representations.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

ERP evidence of semantic processing in children with ASD

DiStefano

Şentürk

Jeste

2019

Developmental Cognitive Neuroscience

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“…That is, the absence of an N400 effect might be attributed to impaired verbal abilities or lower intelligence, and not to the autistic condition itself. Other research demonstrated that children with autistic disorder and Asperger syndrome had a similar N400 amplitude as controls for incongruent versus congruent word pairs, though in the children with autistic disorder the N400 effect was delayed (Méndez, Sans, Abril, & Valdizan, 2009;Valdizan et al, 2003). In adults with ASD, Strandburg et al (1993) also found a clear N400 effect for meaningless word pairs relative to meaningful word pairs (e.g.…”

Section: Integrating Words Into Context -The N400 Effectmentioning

confidence: 95%

“…We hypothesized that if high-functioning adults with ASD make less use of sentence context and focus more on the meaning of the individual words, their semantic expectations might be less strong, which should give rise to reduced N400 effects. Because adults with HFA and Asperger syndrome may differ in the way they process linguistic information, we will explore whether these subgroups differ in semantic processing (Jolliffe & Baron-Cohen, 1999, 2000Méndez et al, 2009;Valdizan et al, 2003).…”

Section: Integrating Words Into Context -The N400 Effectmentioning

confidence: 99%

Exceptions and anomalies: An ERP study on context sensitivity in autism

et al. 2010

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Several studies have demonstrated that people with ASD and intact language skills still have problems processing linguistic information in context. Given this evidence for reduced sensitivity to linguistic context, the question arises how contextual information is actually processed by people with ASD. In this study, we used event-related brain potentials (ERPs) to examine context sensitivity in high-functioning adults with autistic disorder (HFA) and Asperger syndrome at two levels: at the level of sentence processing and at the level of solving reasoning problems. We found that sentence context as well as reasoning context had an immediate ERP effect in adults with Asperger syndrome, as in matched controls. Both groups showed a typical N400 effect and a late positive component for the sentence conditions, and a sustained negativity for the reasoning conditions. In contrast, the HFA group demonstrated neither an N400 effect nor a sustained negativity. However, the HFA group showed a late positive component which was larger for semantically anomalous sentences than congruent sentences. Because sentence context had a modulating effect in a later phase, semantic integration is perhaps less automatic in HFA, and presumably more elaborate processes are needed to arrive at a sentence interpretation.

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“…We can highlight the studies by Arunachalam and Luyster (2016), and Eigsti and Schuh (2016), who have focused on the processes underlying the lexical access of children with autism. The majority of the previous studies at the neuropsychological level have focused on identifying brain processing differences between children with and without ASD using neuroimaging techniques (DiStefano, Senturk & Jeste, 2019;Ribeiro, Valasek, Minati & Boggio, 2013;McCleery et al, 2010;Mendez, Sanz, Abril & Valdizan, 2009). Results show substantial heterogeneity in performance, as well as differences depending on the proposed task: whereas the Ribeiro et al, (2013) and McCleery et al, (2010) studies found different responses in children with and without ASD, the Mendez et al, (2009) and DiStefano et al, (2019) studies showed a similar semantic processing pattern, although the ASD group "is characterized by delayed speed of processing and limited integration with mental representations" (DiStefano et al, 2019, p. 100640).…”

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confidence: 99%

Semantic processing in children with autism spectrum disorder

Moreno¹,

Asunción²,

Cerezuela³

2021

Revista INFAD de Psicología

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El presente estudio analizó el procesamiento semántico de un grupo de niños con trastorno del espectro autista (n= 24), con el objetivo principal de averiguar si presentan diferencias en comparación con un grupo de niños con desarrollo típico (n = 24). Para ello, se realizó un análisis del contenido de los ítems del subtest de información del WPPSY-III, estableciendo una serie de categorías en función del tipo de demanda semántica requerida: asociación significante-significado, relación experiencial y conocimiento general. Los resultados obtenidos apoyan la idea de que los niños con autismo realizarían un procesamiento semántico de la información de la misma manera que los niños sin autismo, pero necesitarían más tiempo para asumir y establecer dicho procesamiento semántico.

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13. Event-related potentials (N 400) in autistic children

Cited by 7 publications

References 0 publications

ERP evidence of semantic processing in children with ASD

ERP evidence of semantic processing in children with ASD

Exceptions and anomalies: An ERP study on context sensitivity in autism

Semantic processing in children with autism spectrum disorder

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