Abstract:Purpose: To formulate and characterize the bi-layer tablet of doxycycline immediate release and flurbiprofen sustained release. Method: Bi-layer tablets were formulated by wet granulation method. Ethyl cellulose and HPMC K 100 were used as polymer for sustained release layer. Five immediate release formulations were developed with varying excipients. Bi-layer tablets were evaluated by pre formulation and post formulation parameters as stated by USP. Dissolution was conducted in 0.1 N HCl and 6.8 phosphate buff… Show more
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