Untitled

Mali, Rahul K.

doi:10.22377/ajp.v11i02.1299

Cited by 2 publications

(3 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dissolution medium used contains pH 6.8 phosphate buffer in type 2 apparatus operated at a speed of 50 rpm for 30 min and analysed at 257 nm as per USP. One of the main goals in SD processing is to achieve an improvement in the dissolution rate of OM and the results obtained are comparitively equivalent with the literature reports in tems of drug release of OM with polaxmer 407, 9 faster than OM with cyclodextrin. 26 Faster than OM with VA64 27 and faster than OM with soluplus.…”

Section: Discussionsupporting

confidence: 75%

“…Solid dispersions with mass ratio of OM to PVP K30 ranging from 1:0.5 to 1:1.5 were formulated by solvent evaporation method. 9 In brief, PVP K30 was dissolved in ethanol, followed by addition of OM. Ultrasonication at room temperature was done for about an hour to dissolve the drug completely 10 and the remaining solvent was subjected to reduced pressure for evaporation.…”

Section: Preparation Of Olmesartan Medoxomil Solid Dispersionmentioning

confidence: 99%

See 1 more Smart Citation

Solid State Characterization of Olmesartan medoximil Solid Dispersion and in-silico Formulation Design using Quality by Design Techniques Engendered by Definitive Screening Design

Kala¹,

Chinni²

2021

JYP

View full text Add to dashboard Cite

Objectives: Olmesartan medoxomil (OM) is employed for treating patients who are intolerant of ACE inhibitors. The challenge to the researchers is because of its poor oral bioavailability and poor solubility. The approach for this problem is to use a hydrophilic carrier in formulation of oro-dispersible tablet (ODT) which presents a suitable way to improve the bioavailability by using quality by design (QbD) techniques with design of experiments (DoE) using definitive screening design (DSD) which produce a robust and rugged formulation. Methods: The focus of the research was to formulate OM/PVP solid dispersion (SD) and formulation of an Oro dispersible tablet (ODT) by QbD techniques. The main focus of this research is to provide a rugged and robust formulation using QbD concept with the application of Definitive screening design for optimization. Results: The dissolution studies of OM/PVP K30 1:1% w/w showed full release within 30 min which may be attributed due to the hydrogen bond formation between OM and PVP K30 in the FTIR spectra which enhanced the solubility. The disintegration and dissolution results were found to be satisfactory and meeting the desired quality target product profile (QTPP). Conclusion: The present research highlights a thorough understanding of the dosage form development with the knowledge of the critical risks involved in formulation to have an impact on critical quality attributes (CQAs). The critical material attributes (CMAs) were refined by DoE using definitive screening design (DSD) to develop design space.

show abstract

Section: Discussionsupporting

confidence: 75%

Section: Preparation Of Olmesartan Medoxomil Solid Dispersionmentioning

confidence: 99%

Solid State Characterization of Olmesartan medoximil Solid Dispersion and in-silico Formulation Design using Quality by Design Techniques Engendered by Definitive Screening Design

Kala¹,

Chinni²

2021

JYP

View full text Add to dashboard Cite

show abstract

“…The physical mixture of RIF and TRIS in a molar ratio of 2:1 was prepared (in triplicate) by a simple mixing method using a glass mortar and pestle for 2 min. , …”

Section: Methodsmentioning

confidence: 99%

Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study

Queiroz,

Barros,

de Sousa

et al. 2024

Mol. Pharmaceutics

View full text Add to dashboard Cite

Rifampicin (RIF) is an antibiotic used to treat tuberculosis and leprosy. Even though RIF is a market-available drug, it has a low aqueous solubility, hindering its bioavailability. Among the strategies for bioavailability improvement of poorly soluble drugs, coamorphous systems have been revealed as an alternative in the increase of the aqueous solubility of drug systems and at the same time also increasing the amorphous state stability and dissolution rate when compared with the neat drug. In this work, a new coamorphous form from RIF and tromethamine (TRIS) was synthesized by slow evaporation. Structural, electronic, and thermodynamic properties and solvation effects, as well as drug−coformer intermolecular interactions, were studied through density functional theory (DFT) calculations. Powder X-ray diffraction (PXRD) data allowed us to verify the formation of a new coamorphous. In addition, the DFT study indicates a possible intermolecular interaction by hydrogen bonds between the available amino and carbonyl groups of RIF and the hydroxyl and amino groups of TRIS. The theoretical spectra obtained are in good agreement with the experimental data, suggesting the main interactions occurring in the formation of the coamorphous system. PXRD was used to study the physical stability of the coamorphous system under accelerated ICH conditions (40 °C and 75% RH), indicating that the material remained in an amorphous state up to 180 days. The thermogravimetry result of this material showed a good thermal stability up to 153 °C, and differential scanning calorimetry showed that the glass temperature (T g ) was at 70.0 °C. Solubility studies demonstrated an increase in the solubility of RIF by 5.5-fold when compared with its crystalline counterpart. Therefore, this new material presents critical parameters that can be considered in the development of new coamorphous formulations.

show abstract

Untitled

Cited by 2 publications

References 20 publications

Solid State Characterization of Olmesartan medoximil Solid Dispersion and in-silico Formulation Design using Quality by Design Techniques Engendered by Definitive Screening Design

Solid State Characterization of Olmesartan medoximil Solid Dispersion and in-silico Formulation Design using Quality by Design Techniques Engendered by Definitive Screening Design

Preparation and Characterization of a Rifampicin Coamorphous Material with Tromethamine Coformer: An Experimental–Theoretical Study

Contact Info

Product

Resources

About