129Xe NMR in study of tissues and plants

Abstract

The high sensitivity of the 129Xe nuclear magnetic resonance (NMR) chemical shift to the environment was used for characterization of biological tissues and plants. The xenon gas was dissolved under moderate pressure by means of a special device in small pieces of human and animal tissues (heart, muscle, lung, kidney, liver, spleen, brain, sinew, cartilage and hypodermic fat) or plants (leaves, stems, grains, fruits) and the NMR parameters were measured in vitro. The observed line with the chemical shift '-180 ppm was attributed to the xenon located in various cellular structures such as lipid shells, intracellular formations. A xenon spectrum in the lungs obtained in vitro coincides with that in the lungs of a mouse measured in vivo by other investigators. The NMR parameters were found to reveal noticeable distinctions between normal and tumour-affected tissues. The analysis of the 129Xe NMR spectra of the sinew and the cartilage revealed the dependence of the magnetic parameters on the age of the substance. This fact could be accounted for by the changes of the absorption ability of a biological system due to age transformations. The results obtained in comparison with biochemical data reveal the promissory outlook of 129Xe NMR for the investigation of the state of biological tissues and for medical diagnostics.

Hyperpolarized 129Xe imaging of the brain: Achievements and future challenges

“…Additionally, due to the high lipophilicity of xenon, HP 129 Xe imaging may also be useful for brain cancer detection. Although there were two preliminary studies on this application, 103,104 the validation of HP 129 Xe brain imaging for use in cancer detection will require further proof-of-concept studies.…”

Detection of radiation effects in polymer gel dosimeters using129Xe NMR

“…129 Xe NMR Measurements of changes in the NMR chemical shift of 129 Xe have been previously used widely as a sensitive probe of physical and chemical environments, and applications of xenon spectroscopy range from materials science (Morgan et al 1999, Yang et al 1998, Jameson et al 1997, Miller et al 1993, Nagasaka et al 2000, Miyoshi et al 1997, Song et al 1995, Pietraß et al 1999, Schanz and Veeman 1997 to biological (Rubin et al 2001, Bifone et al 1996, Swanson et al 1997, Wolber et al 2000, Moller et al 1999, Il'yasov et al 1999, Mugler et al 1997 uses. Xenon displays a large range of chemical shift caused by distortions in the electron cloud surrounding the nucleus, which changes the effective shielding of the nucleus.…”

10.1007/s10786-008-1005-9

“…The most rigorous method is based on the use of accelerated particle beams [3,4]. The most rigorous method is based on the use of accelerated particle beams [3,4].…”