1273 Low Vitamin D Levels in Nonalcoholic Fatty Liver Disease Associate With Insulin Resistance and Liver Injury Progression via Immune Nk Mechanism

Mahmud, Mahamid; Abdullah, Idri; Ghantous, R.; Amer, Johnny; Safadi, Rifaat

doi:10.1016/s0168-8278(12)61285-9

Journal of Hepatology

2012

DOI: 10.1016/s0168-8278(12)61285-9

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1273 Low Vitamin D Levels in Nonalcoholic Fatty Liver Disease Associate With Insulin Resistance and Liver Injury Progression via Immune Nk Mechanism

Mahamid Mahmud¹,

Idri Abdullah²,

R. Ghantous³

et al.

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“…Interventions ameliorating liver disease, metabolic profile, and bone mineralization, including lifestyle-induced weight loss, should be encouraged and pursued as first-line treatments in all NAFLD patients [9]. Within lifestyle factors, increasing attention is being devoted to understand the role of nutritional deficiencies, including insufficient vitamin D intake, which is much more common than traditionally thought and is being associated to extraskeletal metabolic disorders, including obesity, diabetes, and NAFLD, independently of traditional risk factors [16][17][18][19][20]. The knowledge of the exact role and mechanisms whereby vitamin D and other oligoelements may affect intermediate metabolism and insulin sensitivity may lead to simple, feasible, and effective measures targeting both bone and metabolic health [21,22].…”

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Non-alcoholic fatty liver, adipose tissue, and the bone: a new triumvirate on the block

Musso

2012

Endocrine

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In the latest years, a growing body of evidence has connected metabolic syndrome and obesity to bone loss and osteoporosis [1], thereby challenging the conventional view that excessive body weight protects against osteoporosis through increased mechanical load to the skeleton and enhanced cortical bone deposition [2]. In a parallel way, available data suggest that excess body weight may be detrimental to the skeleton, and that excessive adipose tissue plays a key role in this relationship [3]. Within this frame of research, recent studies focused on the relationship between bone health and non-alcoholic fatty liver (NAFLD), the hepatic manifestation of the metabolic syndrome, which recognizes in altered adipose tissue adipokine secretion a key pathogenic factor [4]. The two published studies on endocrine add importantly to the existing literature on the association between NAFLD and osteoporosis. First, ultrasonographic NAFLD was linked to low bone mass in a large cohort of Korean postmenopausal women, independently of age, BMI, smoking status, alcohol intake, and metabolic syndrome [5]. Second, the effect of a multidisciplinary weight-losing regimen on NAFLD, bone mineral density (BMD), and adipokine profile was assessed in post-puberal obese adolescents: weight loss improved NAFLD, BMD, insulin resistance, and plasma lipids. Importantly, bone mineral content changes were related to a reduction in insulin resistance and plasma leptin levels [6]. Consistent with these data, a recent crosssectional study, connected the histological severity of NAFLD to the degree of BMD changes in obese children [7].Together with existing literature, these data strengthen the view that adipose tissue, the bone, and the liver are functionally interrelated organs and cooperate in regulating bone remodeling, glucose homeostasis, lipid and energy metabolism, through hormonal mediators that are only lately being unraveled (Table 1). As an example, insulin activates the osteoblast insulin receptor to increase bone formation and resorption and release of undercarboxylated osteocalcin into the systemic circulation, and adipose tissue-derived adipokines leptin and adiponectin can alter bone remodeling by either stimulating resorption or suppressing bone formation.Reciprocally, the bone may be not only a target of visceral adipose tissue-released mediators, but also a metabolically active regulator of energy balance through the secretion of hormone and peptide signals, including undercarboxylated osteocalcin, a bone-specific secreted protein that enhances pancreatic b-cell viability and function, increases insulin and adiponectin secretion, and reduces fat mass and lipolysis [3,8,9] (Table 1). Perhaps the best evidence of the complex relationship between bone health and energy metabolism is provided by two lines of data: the first is represented by the experiments of Fulzele et al. [10], where mice harboring selective osteoblast deletion of the insulin receptor developed insulin resistance, obesity, fatty liver, and osteopenia, alterations...

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Non-alcoholic fatty liver, adipose tissue, and the bone: a new triumvirate on the block

Musso

2012

Endocrine

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1273 Low Vitamin D Levels in Nonalcoholic Fatty Liver Disease Associate With Insulin Resistance and Liver Injury Progression via Immune Nk Mechanism

Cited by 1 publication

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Non-alcoholic fatty liver, adipose tissue, and the bone: a new triumvirate on the block

Non-alcoholic fatty liver, adipose tissue, and the bone: a new triumvirate on the block

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