1271: A Meta-Analysis of Early Administration of Vasopressor in Septic Shock: Is There Mortality Benefit?

Gordon, David; Chan, Caleb; Tran, Quincy; Bzhilyanskaya, Vera; Bracey, Alexander; Yazdanpanah, Fariba; Downton, Katherine; Rao, Tejusve; Schwartz, Bruce A.; Milzman, Dave

doi:10.1097/01.ccm.0000730972.05471.29

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“…30 Both the lower length of ICU stay in our cohort and the low mortality rate may be explained by early admission to the ICU and the timely treatment established in the PICU. Early vasopressor use has been associated with a reduction in all-cause mortality in other studies, 38 and its early use is recommended to reduce hypotensive time. 39 Limitations to this study include its retrospective nature which implies causation could not be determined, only associations, and its single-centered approach.…”

Section: Discussionmentioning

confidence: 93%

Characterization of Pediatric Patients with Rheumatological Diseases Admitted to a Single Tertiary Health Hospital's Pediatric Intensive Care Unit in Latin America

Erazo-Martínez

Ruiz-Ordóñez

Álvarez

et al. 2022

J Pediatr Intensive Care

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Most autoimmune diseases (AIDs) during childhood debut with more severe and aggressive forms, with life-threatening conditions that increase the need for intensive care therapy. This study describes the clinical, laboratory, and health outcome features of pediatric patients with AIDs admitted to the pediatric intensive care unit (PICU). This is a retrospective cross-sectional study that included the clinical records of all pediatric patients with AIDs admitted to the PICU between 2011 and 2020 in Cali, Colombia. In total, 225 PICU admissions from 136 patients were evaluated. Median age was 13 (11–15) years, and the median disease duration was 15 (5–38.5) months. Systemic lupus erythematosus was the most prevalent disease (91, 66.9%), followed by vasculitis (27, 19.8%). The leading cause of PICU admission was AID activity (95, 44.3%). C-reactive-protein levels were associated with infections (p <0.0394). Mortality occurred in 12 (8.8%) patients secondary to AID activity, primarily, diffuse alveolar hemorrhage (6, 50%). A longer disease duration was associated with mortality (p <0.00398). AID activity was the leading cause of PICU admission and mortality. Pulse steroid therapy, mechanical ventilation, and inotropic and vasopressor support were associated with nonsurvival.

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Section: Discussionmentioning

confidence: 93%