1263 Search of an Ideal Solution for the Pre-Immersion of Titan® Penile Implant and Comparison With Inhibizone

Dhabuwala, C.B.; Kumar, Andrew; John, Alexander; Rajpurkar, Atul

doi:10.1016/j.juro.2010.02.821

Cited by 1 publication

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“…In this article we report data that show one vial of IV trimehtoprim/sulfamethoxazole diluted with a small amount of saline creates ZOI equivalent or better than rifampicin/minocycline against common infecting skin organisms such as S. epidermidis and S. lugdunensis . Zones on the Titan prosthesis against the more pathogenic infecting organisms like S. aureus , Pseudomonas , and Enterococcus [17] are also demonstrated to be statistically significantly better than InhibiZone. Undiluted trimethoprim/polymixin B ophthalmic solution (Polytrim) showed almost equal efficacy compared with trimehtoprim/sulfamethoxazole and more activity than InhibiZone for the more aggressive bacteria.…”

Section: Discussionmentioning

confidence: 94%

“…Coloplast's hydrophilic coating allows the physician to tailor his “dip.” Dhabuwala et al. reported zones of inhibition (ZOI) against S. epidermidis and E. coli with a dip solution of rifampicin and gentamicin that were equal or better than those created from the AMS product or a Coloplast device dipped in vancomycin and gentamicin [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Anti-Infection Dip Suggestions for the Coloplast Titan Inflatable Penile Prosthesis in the Era of the Infection Retardant Coated Implant

Wilson¹,

Salem

Costerton

2011

The Journal of Sexual Medicine

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Introduction Infection is the worst complication seen with inflatable penile prosthesis (IPP). Both the American Medical Systems (AMS) and Coloplast IPP have infection retardant coatings. AMS is coated at the factory with rifampicin and minocycline (InhibiZone). The Coloplast IPP has a hydrophilic coating covalently bonded to its components that will absorb any aqueous solution before implantation and provides increased surface lubricity to decrease bacterial adherence. Aim We tested several antibiotic dips comparing zones of inhibition (ZOI) against five commonly infecting bacteria with coated Coloplast implants. Results were compared with those ZOI created with strips of an AMS IPP precoated with InhibiZone. Methods Pieces of sterile Coloplast Titan IPP were dipped in (i) trimethoprim/polymixin B ophthalmic solution; (ii) trimethoprim/sulfamethoxazole infusion solution; (iii) bacitracin; (iv) rifampicin/minocycline; and (v) rifampin/trimehtoprim/sulfamethoxazole. ZOI for the Titan strips and for AMS InhibiZone coated strips were tested against Staphylococcus epidermidis, Staphylococcus lugdunensis, Staphylococcus aureus, Pseudomonas, and Enterococcus. Main Outcome Measure ZOIs of the Coloplast Titan for each of the medicated solutions were compared with ZOI created by undipped strips of a sterile InhibiZone coated IPP placed on plates of the identical bacteria. Results All dips except bacitracin showed ZOI ≥ InhibiZone (P ≥ 0.005) for most organisms. Because of broad-spectrum effectiveness, ease of handling, and cost, infusion vial of trimehtoprim/sulfamethoxazole seemed optimal at this time. If trimehtoprim/sulfamethoxazole is unavailable; the ZOI with Polytrim ophthalmic solution zones were almost as good. Conclusions The Coloplast strips when dipped in several solutions showed equal or significantly larger ZOI against commonly infecting organisms than the InhibiZone coated strips. At the present time using off the shelf trimethoprim sulfamethoxazole infusion solution seems optimum. The flexibility of choosing the drug eluting from the Coloplast device seems promising in the changing bacterial environment.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%