1263: Improving Survival Through the Implementation of the Abcdef Bundle in a Large Community Hospital

The effect of the ABCDE/ABCDEF bundle on delirium, functional outcomes, and quality of life in critically ill patients: A systematic review and meta-analysis

“…Characteristics of the 18 included studies are reported in Table 1. They were published between 2014 and 2021 and comprised 13 journal articles (Balas et al, 2014;Barnes-Daly et al, 2017;Bounds et al, 2016;DiSabatino and Grami, 2016;Hsieh et al, 2019;Kram et al, 2015;Lee et al, 2020;Malik et al, 2021;Negro et al, 2018;Patel et al, 2014;Pun et al, 2019;Schallom et al, 2020;Sosnowski et al, 2018), four conference abstracts (Cape et al, 2018;Loffink et al, 2018;Zheng et al, 2016;Zhorne et al, 2018), and one dissertation (Jacob, 2017). A total of 102 intensive care units and 29,576 participants were included in the review.…”

“…Study sample sizes ranged from 30 to 15,226 participants. There were seven multi-centred studies (Balas et al, 2014;Barnes-Daly et al, 2017;Bounds et al, 2016;DiSabatino and Grami, 2016;Hsieh et al, 2019;Pun et al, 2019;Schallom et al, 2020) and 11 single-centre studies (Kram et al, 2015;Lee et al, 2020;Malik et al, 2021;Negro et al, 2018;Patel et al, 2014;Sosnowski et al, 2018;Cape et al, 2018;Loffink et al, 2018;Zheng et al, 2016;Zhorne et al, 2018;Jacob, 2017). Most participants (n = 22,911 [77.5%]) were recruited from general intensive care units (n = 90) that admitted a mix of medical and surgical patients.…”

“…Most participants (n = 22,911 [77.5%]) were recruited from general intensive care units (n = 90) that admitted a mix of medical and surgical patients. Thirteen studies were conducted in the United States Of America (USA) (Balas et al, 2014;Barnes-Daly et al, 2017;Bounds et al, 2016;DiSabatino and Grami, 2016;Hsieh et al, 2019;Kram et al, 2015;Pun et al, 2019;Schallom et al, 2020;Cape et al, 2018;Loffink et al, 2018;Zheng et al, 2016;Zhorne et al, 2018;Jacob, 2017), while one each was conducted in Korea (Lee et al, 2020), Italy (Negro et al, 2018), India (Malik et al, 2021), United Kingdom (Patel et al, 2014) and Australia (Sosnowski et al, 2018).…”

Effectiveness of the ABCDEF bundle on delirium, functional outcomes and quality of life in intensive care patients: a study protocol for a randomised controlled trial with embedded process evaluation

“…3 To date, published research of the ABCDEF bundle has described positive short-term clinical outcomes including mortality, length of stay in ICU and hospital. [3][4][5][6][7][8][9][10][11] It is a logical progression to investigate if patient-related benefits are realised once they are discharged from hospital.…”

“…16 The current body of evidence that explores the effect of the ABCDEF bundle suggests promising outcomes for the ICU patient community but is primarily based on before-after studies. [3][4][5][6][7][8][9][10][11] To our knowledge, there are no adequately powered randomised controlled trials (RCTs) focused on patient outcomes related to the ABCDEF bundle compared with standard interdisciplinary healthcare in the ICU. Therefore, a rigorous RCT has been chosen as the methodology to examine the ABCDEF bundle and its effect on ICU survivor's short-term and long-term outcomes.…”