125i-Labelled Fibrinogen Test Adapted for Routine Screening for Deep-Vein Thrombosis

Vv, Kakkar; Nicolaides, Andrew; Renney, J. T. G.; Friend, John; Clarke, Maxine

doi:10.1016/s0140-6736(70)90769-5

Cited by 230 publications

(49 citation statements)

References 3 publications

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“…In order to avoid unnecessary exposure to the risk of hemorrhagic complications due to anticoag ulant treatment [4], the need for confirma tive diagnosis by objective methods is widely accepted. The gold standard for the diagno sis of DVT, contrast venography [5], is an invasive, often painful and expensive tech nique that requires special expertise [6], Therefore several noninvasive alternatives have been developed, of which impedance plethysmography (IPG) [7][8][9][10], ultrasonog raphy [11,12] and l25I-fibrinogen leg scan ning [13] have extensively been evaluated. IPG has shown to be a practical noninvasive alternative for the diagnosis of proximal DVT of the leg in outpatients [8][9][10], In the past, laboratory assays have also been inves tigated to establish their potential role in the diagnosis of DVT [14][15][16][17][18][19][20], Most of these assays were based upon the idea that the presence of products in the circulation, re sulting from plasmin-mediated lysis of fibrin(ogen), might be a useful marker of the thrombotic event.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of <i>D</i>-Dimer for Deep Venous Thrombosis in Outpatients

Kroneman

Bergen²,

Knot³

et al. 1991

Pathophysiol Haemos Thromb

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We have studied the diagnostic value for deep venous thrombosis (DVT) of an enzyme immunoassay (EIA) for the detection of D-dimer in plasma of 239 consecutive outpatients suspected of having DVT by their general practitioner. DVT was confirmed by impedance plethysmography in 60 patients. Using the 95th percentile range of 42 healthy volunteers, the sensitivity for the detection of DVT was 92 %, with a specificity of 21 %. In our population with a prevalence of 25%, the D-dimer EIA showed a negative predictive value of 88 % and a positive predictive value of 28%. We conclude that this D-dimer ELISA has limited value, either to confirm or to exclude DVT in outpatients.

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Section: Introductionmentioning

confidence: 99%

Diagnostic Value of <i>D</i>-Dimer for Deep Venous Thrombosis in Outpatients

Kroneman

Bergen²,

Knot³

et al. 1991

Pathophysiol Haemos Thromb

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“…Follow-up included fibrinogen scan [6], per formed daily during 14 days. A unilateral rise of 20% on 2 consecutive days was considered to be a positive scan.…”

Section: Methodsmentioning

confidence: 99%

Prophylaxis of Deep Venous Thrombosis with a Low-Molecular-Weight Heparin (Kabi 2165/Fragmin®) in Stroke Patients

Prins¹,

Gelsema

Sing

et al. 1989

Pathophysiol Haemos Thromb

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In a group of 60 patients in the acute phase of an ischemic stroke the assumption that low-molecular-weight heparin Kabi 2165 in the dose of 2 × 2,500 anti-Xa units s.c. could prevent thromboembolic complications was tested using a double-blind, placebo-controlled, randomized trial design. Thirty patients were allocated to each group. Both treatment groups were comparable with regard to neurological status and general condition. In the Kabi 2165 group there were 6 cases of deep venous thrombosis (DVT) compared to 15 in the placebo group (p = 0.05). In the placebo group there were 4 deaths during the trial versus 9 in the Kabi-2165-treated group (NS). Cerebral bleeding complicated 2 cases in the placebo group versus 4 in the Kabi 2165 group (NS). These results indicate that in ischemic stroke patients Kabi 2165 2 × 2,500 anti-Xa units s.c./24 h reduces the frequency of DVT. Because of the small number of patients it is impossible to evaluate the safety.

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“…Following the initial clerking and baseline investi-gations, each patient received 60 mg of KI orally and then 30 mg on each subsequent day in order to block thyroidal uptake of isotope. The initial dose of 125I-labelled human fibrinogen (Radiochemical Centre Amersham) was injected intravenously as soon as possible after admission and lower-limb scanning was carried out approximately 24 h later according to the method of Kakkar et al [3], This was repeated daily, and leg vein thrombosis was diagnosed only if there was a difference in the count of 20% between adjacent positions on the same leg or similar positions on the two legs.…”

Section: Methodsmentioning

confidence: 99%

Beta-Thromboglobulin Levels in Relation to Myocardial Infarction – Preliminary Observations

Simmonds¹,

O'Malley²,

Maskill³

et al. 1980

Acta Haematol

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34 patients with myocardial infarction were studied with daily measurements of β-thromboglobulin (BTG) and ¹²⁵I fibrinogen scanning in order to detect deep-venous thrombosis (DVT). Serial levels of BTG were unhelpful in the early detection of this condition, which occurred in 7 of the patients studied. 5 of the patients with DVT had received prophylactic heparin and 6 of them were non-smokers. This latter observation is in support of previous studies suggesting an increased incidence of DVT after myocardial infarction in non-smokers as compared to smokers.

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125i-Labelled Fibrinogen Test Adapted for Routine Screening for Deep-Vein Thrombosis

Cited by 230 publications

References 3 publications

Diagnostic Value of <i>D</i>-Dimer for Deep Venous Thrombosis in Outpatients

Diagnostic Value of <i>D</i>-Dimer for Deep Venous Thrombosis in Outpatients

Prophylaxis of Deep Venous Thrombosis with a Low-Molecular-Weight Heparin (Kabi 2165/Fragmin®) in Stroke Patients

Beta-Thromboglobulin Levels in Relation to Myocardial Infarction – Preliminary Observations

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