125 Overexpression of cyclin D in Bowen's disease

Bito, Toshinori; Nagano, Tohru; Ueda, Masataka; Ichihashi, M.

doi:10.1016/0923-1811(95)93838-r

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“…Negative or only weak staining with anti-cyclin D1 antibody was observed in human normal tissues and benign tumors of skin and other organs [3,10,14,26,34]. In normal adult mouse skin, cyclin D1 immunostaining was not detected [27].…”

Section: Discussionmentioning

confidence: 87%

“…Bito et al found no significant difference in cyclin D overexpression (using rabbit polyclonal anti-cyclin D) between UV-related (22 cases) and UV-unrelated SCCs (23 cases), though UV-related SCCs had a significantly higher incidence of p53 positivity [3]. In the present study, we used a large sample for analysis of nonmelanocytic skin cancer, and showed that the expression of cyclin D1 was significantly higher in dysplasia and in cancer nests in strongly sun-exposed areas than in those in weakly sunexposed area, especially in the cases of SCC and BOD.…”

Section: Discussionmentioning

confidence: 96%

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Overexpression of cyclin D1 in nonmelanocytic skin cancer

et al. 2000

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Although the overexpression of cyclin D1 has been believed to play important roles in neoplastic transformation of some tumors, little is known about the function of cyclin D1 protein in carcinogenesis in human skin. A total of 307 patients with nonmelanocytic skin cancer, being 46 with Bowen's disease (BOD), 134 with squamous cell carcinoma (SCC) and 127 with basal cell carcinoma (BCC), were investigated immunohistochemically using monoclonal antibody to cyclin D1 by the LSAB method, to assess the expression of cyclin D1 in skin cancer including its precursors. The positive rates of cyclin D1 immunostaining in BOD, SCC and BCC were 63.0%, 69.4% and 54.3%, respectively. The positive rates in dysplasia adjoining BOD, SCC and BCC were 43.6%, 67.9% and 59.8%, respectively. In morphologically normal skin, however, only 2 cases, 1 of SCC and 1 of BCC, exhibited positive staining. These findings suggested that overexpression of cyclin D1 is an early event in dysplastic lesions of skin. Overexpression of cyclin D1 was related to sun exposure, especially in dysplasia of SCC. The score for cyclin D1 expression in dysplasia of BCC was correlated with age. Expression of cyclin D1 markedly increased from normal skin through dysplasia to BOD, but was not significantly related to the degree of SCC differentiation. These findings demonstrate that the effect of cyclin D1 overexpression is restricted to proliferation of cells, so that they gain a growth advantage, but their differentiation is not increased. Comparison with the results for p53 protein expression in these tumors, a significant correlation with cyclin D1 expression was found in dysplasia in BOD and SCC, and in patients with BCC who were less than 74 years old. These findings suggested the hypothesis that prior aberrant p53 expression may affect or regulate the overexpression of cyclin D1.

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