125 Ono-8539, a Novel Ep1 Receptor Antagonist, Suppresses Bladder Hyperactivity via Excessive Production of Prostaglandin E2 (Pge2) Induced by Intravesical Instillation of Atp in Urodynamic Evaluation of Cynomolgus Monkeys

Okada, Hiroshi; Konemura, Takashi; Maruyama, Toshiro

doi:10.1016/s1569-9056(10)60130-3

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Prostaglandin E2: Ep1-receptor Antagonists1

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“…In a study in cynomolgus monkeys, the EP-1 receptor antagonist ONO-8539 was found to significantly increase bladder capacity without increasing residual volume. 9 However, when it was evaluated in a phase 2 clinical trial in OAB, the investigators concluded that it had minimal impact. 10…”

Section: Prostaglandin E2: Ep1-receptor Antagonistsmentioning

confidence: 99%

Drugs and future candidates

Andersson

2013

CUAJ

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Antimuscarinic drugs are still first-line treatment for the symptomsof overactive bladder (OAB) and are associated with good initialresponse rates. Adverse effects and decreasing efficacy overthe longer term do, however, limit their overall effectiveness. Assuch, alternatives to antimuscarinics are needed. The recognitionof the functional contribution of the urothelium, the spontaneousmyocyte activity during bladder filling, and the diversity of nervetransmitters involved in the symptoms of the OAB has sparkedinterest in pharmacologic manipulation of both peripheral andcentral pathophysiology. Some of the treatments currently underinvestigation are discussed in this review.

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Section: Prostaglandin E2: Ep1-receptor Antagonistsmentioning

confidence: 99%