[123I]β-CIT single-photon emission tomography in Parkinson's disease reveals a smaller decline in dopamine transporters with age than in controls

Abstract

[123I]beta-CIT single-photon emission tomography in Parkinson's disease reveals a smaller decline in dopamine transporters with age than controls Tissingh, G.; Bergmans, P.; Booij, J.; Winogrodzka, A.; Stoof, J.C.; Wolters, E.CH.; van Royen, E.A. Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: http://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. In vivo studies using single-photon emission tomography (SPET) and positron emission tomography have shown an age-related decline in the number of striatal dopamine transporters in healthy subjects. We examined ten healthy subjects and 33 de novo patients with Parkinson's disease (PD) using [ 123 I]2β-carbomethoxy-3β-(4-iodophenyl)tropane ([ 123 I]β-CIT) SPET. A clear age-related loss of dopamine transporters was found in the healthy subjects. In the PD group, controlling for the contribution of disease severity, we found a small (compared with controls) but significant decrease with aging, though only in the ipsilateral regions. This aging effect was especially pronounced in younger patients. We conclude that the use of age-correct SPET data in PD, based on studies with healthy subjects, may lead to an underor an overestimation of the striatal binding measures.

Relationship between nigrostriatal dopaminergic degeneration, urinary symptoms, and bladder control in Parkinson's disease

“…We did not find significant correlation between age and binding of [ 123 I]‐FP‐CIT in the striatum or any subregion, but others have found a negative correlation in healthy volunteers(Pirker et al. , 2000) and in patients with PD(Tissingh et al. , 1997).…”

“…, 1997). The correlation with age is not consistent(Tissingh et al. , 1997) and the disease severity exceeds age when it comes to affecting the binding of the marker in patients with PD.…”

Marked disparity between age‐related changes in dopamine and other presynaptic dopaminergic markers in human striatum

“…By contrast, several PET and SPECT radioligand binding studies have reported that DAT decreases with age (Volkow et al . 1994, 1996; Tissingh et al . 1997; Volkow et al .…”

Human Brain Imaging of Dopamine Transporters

“…[ 123 I]β-CIT and [ 123 I]FP-CIT SPECT have a high discriminative power to differentiate PD from normal aging as shown in Figure 7, particularly when the DAT availability in the putamen is evaluated Tissingh et al, 1998). Similar results with a sensitivity and specificity between 95 and 100% have been obtained with [ 99m Tc]TRO-DAT-1 (Weng et al, 2004), suggesting that the three radioligands are equally sensitive in detecting the DA deficit at an early stage of PD.…”