123I-MIBG Myocardial Scintigraphy in the Diagnosis of Lewy Body Dementia

Iodine‐123 Metaiodobenzylguanidine Scintigraphy and Iodine‐123 Ioflupane Single Photon Emission Computed Tomography in Lewy Body Diseases: Complementary or Alternative Techniques?

“…In this patient subgroup, both 123 I‐MIBG scintigraphy and 123 I‐FP‐CIT SPECT showed high diagnostic accuracy (90%) (Table ), confirming the usefulness of both techniques in DLB diagnosis as recently suggested by two separate meta‐analyses . Other authors also demonstrated that myocardial sympathetic and striatal dopaminergic impairments usually coexist in patients with DLB . In the latest guidelines for the diagnosis of DLB, abnormal 123 I‐FP‐CIT SPECT received the greatest importance among various neuroimaging findings being listed as one of the suggestive features of DLB, whereas abnormal 123 I‐MIBG scintigraphy was listed as one of the supportive features of DLB (commonly present in DLB but not proven to have diagnostic specificity) .…”

The usefulness of combined brain perfusion single‐photon emission computed tomography, Dopamine‐transporter single‐photon emission computed tomography, and 123I‐metaiodobenzylguanidine myocardial scintigraphy for the diagnosis of dementia with Lewy bodies

“…DAT‐SPECT was also very useful for diagnosing DLB because of its high sensitivity (79%), confirming the usefulness of other techniques for DLB diagnosis that were recently suggested by two separate meta‐analyses . Other authors also demonstrated that myocardial sympathetic and striatal dopaminergic impairments usually coexist in patients with DLB, and structures of the noradrenaline transporter system in the heart and the dopamine transporter system in the striatum are similar . It remains uncertain whether the combined functional loss of dopaminergic nigrostriatal neurons and sympathetic cardiac neurons is based on this structural similarity.…”