[123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset

Isaias, Ioannis U.; Benti, Riccardo; Cilia, Roberto; Canesi, Margherita; Marotta, Giorgio; Gerundini, Paolo; Pezzoli, Gianni; Antonini, Angelo

doi:10.1097/wnr.0b013e3282ef69f9

Cited by 61 publications

(80 citation statements)

References 24 publications

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“…In PD, reduced dopamine release from nigro-striatal projections results in loss and adaptive down-regulation of DAT binding sites in the striatal region [22]. In line with this notion, and in agreement with studies in de novo and early PD, where 40 to 60% of nigral dopaminergic neurons are lost, [15,23] we found a significantly reduced FP-CIT binding in the caudate and putamen of PD patients. In contrast to the striatal compartment, analysis of FP-CIT labeling in the upper brainstem revealed significantly increased binding in a pontine area adjacent to the floor of the fourth ventricle and extending into the midbrain to the level of the inferior colliculi.…”

Section: Increased Fp-cit Binding In the Lc Areasupporting

confidence: 91%

“…Intravenous administration of 110-140 MBq of FP-CIT (DaTSCAN, GE-Healthcare, UK) was performed 30-40 minutes after thyroid blockade (10-15 mg of Lugol oral solution) in the control subjects and in patients after overnight withdrawal of dopaminergic therapy [15]. Brain SPECT was performed 3 hours later by means of a dedicated triple detector gamma-camera (Prism 3000, Philips, Eindhoven, the Netherlands) equipped with lowenergy ultra-high resolution fan beam collimators (4 subsets of acquisitions, matrix size 128x128, radius of rotation 12.9-13.9 cm, continuous rotation, angular sampling: 3 degree, duration: 28 minutes).…”

Section: Spect Data Acquisition and Processingmentioning

confidence: 99%

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Anticipatory postural adjustments stabilise the whole upper-limb prior to a gentle index finger tap

Caronni

Cavallari

2008

Exp Brain Res

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Section: Increased Fp-cit Binding In the Lc Areasupporting

confidence: 91%

Section: Spect Data Acquisition and Processingmentioning

confidence: 99%

Anticipatory postural adjustments stabilise the whole upper-limb prior to a gentle index finger tap

Caronni

Cavallari

2008

Exp Brain Res

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“…The occurrence of a widespread degeneration of the nigrostriatal dopaminergic pathway for the development of parkinsonian tremor at rest has been previously postulated by Isaias et al (24), who evaluated 20 drug-naïve PD patients, 10 with unilateral akinesia-rigidity at onset and 10 with additional tremor at rest. They reported a mean reduction of 123 I-FP-CIT striatal binding of 42 and 50% for ART and TDT patients, respectively.…”

Section: Discussionmentioning

confidence: 99%

Different patterns of nigrostriatal degeneration in tremor type versus the akinetic-rigid and mixed types of Parkinson's disease at the early stages: Molecular imaging with 123I-FP-CIT SPECT

Schillaci¹

2011

Int J Mol Med

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Abstract. The various associations of motor and non-motor symptoms, the onset of motor complications, the cognitive disorder's appearance and other factors make Parkinson's disease (PD) a heterogeneous syndrome with multiple phenotypes. The necessity of discriminating between different forms of PD could have a role in understanding the pathophysiology of extrapyramidal signs with clinical implications. The aim of this study was to evaluate if there is a relationship between the clinical motor phenotypes of PD and the scintigraphic pattern of 123 I-FP-CIT single photon emission computed tomography (SPECT). We examined 47 patients with early idiopathic PD (25 males; 22 females; mean age 58±2 years) and subdivided them in different clinical forms on the basis of dominance of resting tremor (n=20), bradykinesia plus rigidity (n=20) and the presence of both clinical signs [mixed type (MT, n=7)]. We correlated this status with the semi-quantitative analysis of SPECT with 123 I-FP-CIT. Tremor type patients showed a lower reduction of 123 I-FP-CIT uptake compared to akineticrigid type patients in contralateral caudate (P=0.0139) and putamen (P=0.0028) nuclei. 123I-FP-CIT uptake was higher in the ipsilateral caudate (P=0.0050) and putamen (P=0.0012) of tremor type patients compared to akinetic-rigid type patients. Comparisons of the striatal uptake in the tremor type and akinetic-rigid type patients with the MT patients revealed significant differences only in the ipsilateral and contralateral caudate. Our data indicate that in akinetic-rigid patients the dopaminergic system is more involved compared to that in the tremor type patients and that this difference is present from the initial stage of the disease. Moreover, our results suggest that PD phenotypes could be related not only to the dopaminergic involvement but also to other systems. IntroductionThe relationships between movement disorders and the dopaminergic system have been extensively investigated, both in terms of presynaptic and postsynaptic processes (1). The particular interest in the dopamine active transporter (DAT) is related to the assessment of dopaminergic neuron loss in Parkinson's disease (PD) (2,3) and movement disorders (2,4,5). 123I-FP-CIT is a radiopharmaceutical highly selective for the DAT on the presynaptic processes of the nigrostriatal neurons (6). DAT is located on the plasma membrane of nerve terminals in a small number of neurons in the brain, especially in the striatum and nucleus accumbens, but also in the globus pallidus, cingulate cortex, olfactory tubercle, amygdala and midbrain (7).In idiopathic PD (IPD), 50% of patients complain of slowing up at presentation. The slowness of IPD involves both initiation and execution of movements, particularly sequential and volitional actions (8). About 40% of patients will complain of tremulousness of hands at rest, which improves with action and 80% of them will have an asymmetrical 3-5 Hz rest tremor evident on examination (9). A variant of IPD based on the clinical course is the mixed type (...

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“…Nineteen patients (10 PDSK and 9 PD) also performed a second SPECT with 123 I‐FP‐CIT to measure DAT density. 123 I‐FP‐CIT scans were started 180 min after injection of 182.1 ± 3.9 MBq of 123 I‐FP‐CIT 13. Both 40‐min scans were acquired on a dual‐headed integrated SPECT/CT system (Symbia T2; Siemens, Erlangen, Germany) with 60 projections of 40 sec each, photopeak window of 159 keV ± 15%, matrix 128 × 128, and zoom factor 1.23.…”

Section: Methodsmentioning

confidence: 99%

“…Each image was then delineated employing a whole brain VOI set with 67 predefined regions on the Automated Anatomical Labeling brain atlas 16. Average regional binding values were used to calculate regional estimates of the non‐displaceable binding potential (BP) for caudate nucleus and putamen, using as a reference the average global brain (for BP 5‐IA )10, 17 and the average occipital lobe binding value (for BP FP‐CIT ) 13. Similarly, the standardized uptake value ratio (SUVR FDG ) was calculated for each subject as the ratio of mean count per voxel of basal ganglia VOIs to mean count per voxel of the global 18 F‐FDG brain uptake.…”

Section: Methodsmentioning

confidence: 99%

Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study

Brumberg

Küsters

Al‐Momani

et al. 2017

Ann Clin Transl Neurol

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ObjectiveTo investigate the association between levodopa‐induced dyskinesias and striatal cholinergic activity in patients with Parkinson's disease.MethodsThis study included 13 Parkinson's disease patients with peak‐of‐dose levodopa‐induced dyskinesias, 12 nondyskinetic patients, and 12 healthy controls. Participants underwent 5‐[123I]iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine single‐photon emission computed tomography, a marker of nicotinic acetylcholine receptors, [123I]N‐ω‐fluoropropyl‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)nortropane single‐photon emission computed tomography, to measure dopamine reuptake transporter density and 2‐[18F]fluoro‐2‐deoxyglucose positron emission tomography to assess regional cerebral metabolic activity. Striatal binding potentials, uptake values at basal ganglia structures, and correlations with clinical variables were analyzed.ResultsDensity of nicotinic acetylcholine receptors in the caudate nucleus of dyskinetic subjects was similar to that of healthy controls and significantly higher to that of nondyskinetic patients, in particular, contralaterally to the clinically most affected side.InterpretationOur findings support the hypothesis that the expression of dyskinesia may be related to cholinergic neuronal excitability in a dopaminergic‐depleted striatum. Cholinergic signaling would play a role in maintaining striatal dopaminergic responsiveness, possibly defining disease phenotype and progression.

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[123I]FP-CIT striatal binding in early Parkinson's disease patients with tremor vs. akinetic-rigid onset

Cited by 61 publications

References 24 publications

Anticipatory postural adjustments stabilise the whole upper-limb prior to a gentle index finger tap

Anticipatory postural adjustments stabilise the whole upper-limb prior to a gentle index finger tap

Different patterns of nigrostriatal degeneration in tremor type versus the akinetic-rigid and mixed types of Parkinson's disease at the early stages: Molecular imaging with 123I-FP-CIT SPECT

Cholinergic activity and levodopa‐induced dyskinesia: a multitracer molecular imaging study

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