1225P The progression-free survival of the first-line EGFR-TKI is a strong prognosticator of the second-line osimertinib in non-small cell lung cancer (NSCLC) patients with EGFR-T790M mutation: A real-world study

Abstract

Background: As a third generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI), osimertinib is recommended as standardized treatment for advanced or metastatic non-small cell lung cancer (NSCLC) patients with EGFR-T790M mutation after progressed on first-line EGFR-TKI. Our study aims to investigate the prognostic value of first-line EGFR-TKI on the second-line osimertinib in the real-world practice.Methods: A total of 198 NSCLC patients with EGFR-T790M between 2016 and 2020 were included in this study. All patients were resistant to first-line EGFR-TKI and received osimertinib as second-line therapy. The endpoint was the occurrence of progression on osimertinib. Univariate and multivariate COX regression analysis were used to identify the prognostic value of clinical factors. Log-rank test was conducted to compare survival outcomes of different groups.