1216 Growth of Infants Fed with Nan is in Good Agreement with the Who Growth Standard: A Meta-Analysis

BACKGROUNDIn the absence of breast-feeding and its immunomodulatory factors, supplementation of starter infant formula (IF) with probiotics is currently used to support immune functions and gut development.AIMTo assess whether immune-related beneficial effects of regular dose (107 CFU/g of powder) of the probiotic Bifidobacterium lactis CNCM I-3446 (hereafter named B. lactis) in starter IF supplementation can be maintained with starter IF containing a low dose (104 CFU/g of powder) of B. lactis.METHODThis trial was designed as a pilot, prospective, double-blind, randomized, single-center clinical trial of two parallel groups (n = 77 infants/group) of C-section delivered infants receiving a starter IF containing either low dose or regular dose of the probiotic B. lactis from birth to six months of age. In addition, a reference group of infants breast-fed for a minimum of four months (n = 44 infants), also born by C-section, were included. All groups were then provided follow-up formula without B. lactis up to 12 months of age. Occurrence of diarrhea, immune and gut maturation, responses to vaccinations, and growth were assessed from birth to 12 months. The effect of low-dose B. lactis formula was compared to regular-dose B. lactis formula, considered as reference for IF with probiotics, and both were further compared to breast-feeding as a physiological reference.RESULTSData showed that feeding low-dose B. lactis IF provides similar effects as feeding regular-dose B. lactis IF or breast milk. No consistent statistical differences regarding early life protection against gastrointestinal infections, immune and gut maturation, microbiota establishment, and growth were observed between randomized formula-fed groups as well as with the breast-fed reference group.CONCLUSIONThis pilot study suggests that supplementing C-section born neonates with low-dose B. lactis-containing starter formula may impact immune as well as gut maturation similarly to regular-dose B. lactis, close to the breast-feeding reference.

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“…Mean values for all growth measures through age four months were within 0.5 SD of the median value. 27…”

Section: Resultsmentioning

confidence: 99%

“…Mean values for all growth measures through age four months were within 0.5 SD of the median value. 27 Serious adverse events. Serious adverse events reported throughout the study were ,5% in all groups (3.9%, 1.3%, and 2.3% for low-dose, regular-dose, and BF groups, respectively).…”

Section: Diarrheamentioning

confidence: 99%

Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study

Baglatzi

Gavrili

Stamouli

et al. 2016

Clin Med Insights Pediatr

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“…Reducing the amount of protein in infant formulas could be one way to prevent excessive growth and minimize weight gain during childhood [ 89 102 ]. A meta-analysis of five randomized control trials showed that a diet of optimum quality and quantity protein formula leads to a growth pattern very close to the WHO growth standard at 4 months of age [ 103 ]. As well as increasing the risk of obesity, poor childhood nutrition and defective metabolic programming, have also been shown to trigger other NCDs, such as type 2 diabetes, hypertension, and cardiovascular disease, in later life [ 50 104 105 106 ].…”

Section: Discussionmentioning

confidence: 99%

Burden of Early Life Obesity and Its Relationship with Protein Intake in Infancy: The Middle East Expert Consensus

Jochum

Abdellatif

Adel

et al. 2022

Pediatr Gastroenterol Hepatol Nutr

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Adequate nutrition in early life is proposed to shape a child’s future health by launching the growth trajectory in the proper direction, which helps to avoid negative metabolic programming effects. Protein intake during infancy and early childhood is of great importance, as it plays a key role in infant metabolic programming and the future risk of obesity. Breastfeeding provides the best nutrition in early life, with many benefits tailored for the baby, including the appropriate quantity and quality of proteins. Considering the high prevalence of childhood, and subsequent adult, obesity in the region, a virtual Middle East expert consensus meeting was held to discuss an effective approach for managing childhood obesity. Leading pediatric experts from Bahrain, Egypt, Kuwait, Oman, Qatar, Saudi Arabia, and the United Arab Emirates participated in the meeting. The experts discussed, debated, and agreed on certain directions, including the importance of educating parents, endorsing breastfeeding, and ensuring optimum quantity and quality intake of proteins in early life. This expert consensus may serve as the starting point for healthcare professionals in the region who are interested in shaping a healthy future for the generations to come.

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Proteins, Peptides and Amino Acids: Role in Infant Nutrition

Nutten¹

2016

Nestlé Nutrition Institute Workshop Series

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Proteins are polymers composed of 30 or more amino acids; some of them are essential dietary components, since they are not synthetized by human metabolic processes. They are crucial for healthy growth and development and influence major functions of the body. The infant's first year is a critical time of rapid growth and development, which must be supported by a high rate of protein synthesis. Breast milk, as a single specific food source in the first months of life, is providing the total protein and essential amino acids required. Infant formulas have been designed for infants who cannot be breastfed. They should be similar to breast milk in their composition and their functional outcomes, insuring appropriate growth, optimal development, maturation of the immune system, easy digestion and healthy metabolic programming. By modifying their protein components, specific infant formulas have also been developed for specific needs. For example, partially hydrolyzed (prevention of atopic dermatitis) and extensively hydrolyzed or amino-acid-based infant formulas (reduction in allergy symptoms) have been designed for the management of cow's milk protein allergy. In conclusion, proteins provided via breast milk or infant formula are essential components of the infant's diet; therefore, the specific quality, quantity and conformation of proteins are of utmost importance for healthy growth and development.

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1216 Growth of Infants Fed with Nan is in Good Agreement with the Who Growth Standard: A Meta-Analysis

Abstract: Posters 602 n=6). Laser treatment was offered at a gestational age of 21 (17-26) weeks and delivery occurred at 29 (19-41) weeks.

Cited by 3 publications

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Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study

Effect of Infant Formula Containing a Low Dose of the Probiotic Bifidobacterium lactis CNCM I-3446 on Immune and Gut Functions in C-Section Delivered Babies: A Pilot Study

Burden of Early Life Obesity and Its Relationship with Protein Intake in Infancy: The Middle East Expert Consensus

Proteins, Peptides and Amino Acids: Role in Infant Nutrition

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