1211 POSTER Treatment of Solid Cancers Using a New Cationic Cytolytic Peptide

Szczepanski, C.; Bjerkvig, Rolf; Tenstad, Olav; Thorsen, Frits; Wendelbo, Ingvild; Martı́nez, Alfredo; Baumann, Amanda K.; Prestegarden, Lars

doi:10.1016/s0959-8049(11)70823-1

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2016

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“…Clearly the increase in positive charge density within the structure of (sC18) 2 is one reason for this observation. Recently, also for other CPPs nuclear targeting within cancer cells was observed …”

Section: Resultsmentioning

confidence: 99%

Characterization of a Cell‐Penetrating Peptide with Potential Anticancer Activity

et al. 2016

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Cell‐penetrating peptides (CPPs) are still an interesting and viable alternative for drug delivery applications. CPPs contain considerably high amounts of positively charged amino acids, imparting them with cationic character. Tumor cells are characterized by an enhanced anionic nature of their membrane surface, a property that could be used by CPPs to target these cells. We recently identified a branched CPP that displays a high internalization capacity while exhibiting selectivity for certain tumor cell types. In this study we elucidated this observation in greater detail by investigating the underlying mechanism behind the cellular uptake of this peptide. An additional cytotoxicity screen against several cancer cell lines indeed demonstrates high cytotoxic activity against cancer cells over normal fibroblasts. Furthermore, we show that this feature can be used for delivering the anticancer drug actinomycin D with high efficiency in the MCF‐7 cancer cell line.

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Section: Resultsmentioning

confidence: 99%