121: Pregabalin Therapy in Refractory Uremic Pruritus

Guru, Pramod; Ganguli, Arun; Bains, Ajit; Chaudhary, Sana Mohyud Din; Bhargava, Amit; Lund, Ragnar

doi:10.1053/j.ajkd.2010.02.128

Cited by 3 publications

(3 citation statements)

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“…Prescribing 75 mg of pregabalin every other day for 4 weeks significantly reduced the mean score of the visual analog scale (from 7.72 ± 0.93 at baseline to 5.94 ± 0.36 at the end of the study, p<0.0001). The reported adverse effects were drowsiness, vertigo, sedation and ataxia (27).…”

Section: Antipruritic Effects Of Pregabalin On Uremic Pruritusmentioning

confidence: 99%

Role of Pregabalin in Management of Pruritus: A Literature Review

Foroutan

Nikvarz

2016

J Pharm Pharm Sci

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-Purpose. Pruritus can be one of the distressing symptoms of many dermatologic, systemic, neurologic or psychiatric disorders. In each case, the origin of itch is in the skin and/or the nervous system. Involvement of the nervous system causes neurogenic, psychogenic or neuropathic itch. Itch sensation is transferred to the central nervous system via unmyelinated C-type nerve fibers, and many mediators and receptors engage in the its induction and transmission. Also it has been demonstrated that there are similarities and interactions between neurotransmitters and pathways of pain and itch sensation. Hence, effective drugs in reducing the neuropathic pain such as pregabalin have been studied and used in the management of different itchy conditions. In this narrative review we considered the available published papers dealing with the antipruritic effects of pregabalin. Results of studies conducted in uremic patients show that pregabalin is an effective option in reducing uremic pruritus especially in those who have not responded to antihistamines and topical moisturizers. Data about the effects of pregabalin on other itchy conditions are very limited; however results of the available studies show beneficial effects of this drug in burn patients with more than 5% involvement of the total body surface area, in prurigo nodularis, and in chronic and idiopathic itch. One considerable issue is that the therapeutic effects of pregabalin on uremic pruritus and post burn itch may appear more rapidly than its effects in the other conditions (1-2 weeks vs > 4 weeks). The most reported adverse effects of pregabalin are sedation, dizziness and drowsiness. Whether pregablin can be unequivocally considered as an effective and reasonable choice in the management of pruritus with different causes is a question that should be answered through large scale randomized controlled studies.

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Section: Antipruritic Effects Of Pregabalin On Uremic Pruritusmentioning

confidence: 99%

Role of Pregabalin in Management of Pruritus: A Literature Review

Foroutan

Nikvarz

2016

J Pharm Pharm Sci

View full text Add to dashboard Cite

show abstract

“…In addition to these studies, results of the other studies conducted by Aperis et al (N = 12, duration: 4 weeks), Guru et al (N = 20, duration: 4 weeks), Shavit et al (N = 12, duration: 24 weeks), and Rayner et al (N = 16, duration: 2.5 months) showed that pregabalin significantly reduced the severity of the UP.…”

Section: Discussionmentioning

confidence: 59%

“…However, one considerable issue is the different doses of pregabalin that were used in these studies including 75 mg daily (Solak et al), 75 mg after each dialysis session (Guru et al, Yue et al), and 25 mg daily (Aperis et al 2010) . Moreover, in the study conducted by Shavit et al one, eight, and three patients received pregabalin at the doses of 25 mg thrice weekly, 25 mg/day and 50 mg/day, respectively.…”

Section: Discussionmentioning

confidence: 99%