Abstract:INTRODUCTION:Beta-lactam antibiotics are the backbone of therapy for critically ill patients with sepsis; however, these patients experience pharmacokinetic changes that alter beta-lactam exposure. Adjusting doses for acute kidney injury during the first 48 hours of admission to the ICU may result in suboptimal drug exposure and subject patients to inadequate therapy. We evaluated the association of betalactam antibiotic dose adjustment within the first 48 hours of therapy, on shock-free days in critically ill… Show more
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