120. The outcome of surgical treatment of Gastrointestinal Stromal Tumours (GIST) of the stomach in the Imatinib Era

Stiekema, J.; Kol, Sabrine Q.; Cats, Annemieke; Coevorden, Frits van; Sandick, Johanna W. van

doi:10.1016/j.ejso.2012.06.120

Cited by 1 publication

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“…GISTs prognosis can vary significantly among patients within the same stage. Response to treatment is usually unpredictable and recurrence can occur in 50% of properly resected cases [6] [7]. Many validated prognosis stratification tools are available in the assessment of patient's outcome.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Stromal Tumors: Correlation of Multislice CT Findings to Histopathologic Features and Preliminary Validation of New Scoring System

Mchirgui

Noomene

Chammakhi

et al. 2016

OJRad

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Purpose: The purpose of this study is to demonstrate the correlation between radiologic and pathologic features of the gastrointestinal stromal tumors. Patients and methods: A retrospective review from 2004 to 2014 identified 50 resected cases of confirmed gastrointestinal stromal tumors (GIST) is done. All these lesions were visualized in the first multi-slice computed tomography (MSCT) investigation. Radiologic and pathologic features were reviewed and compared. A radiologic score with MSCT findings was established. Four levels of risk were defined and compared to the Miettinen-Lasota prognostic classification. Results: Mean patients' age was 57.6 with a sexratio (M/F) of 1.17. Of the 50 GISTs lesions, 29 were located in the stomach (58%), 3 in the duodenum (6%), 16 in the small intestine (32%), one in the rectum and one in the great omentum. MSCT images were evaluated for origin and size of the tumor, as well as growth pattern, density before and after contrast, relationship with adjacent structures, presence of lymph nodes, ascitis and metastasis. The presence of mucosal ulceration, calcification, necrosis, cystic area or hemorrhage into the lesion was emphasized for each case. The histologic equivalent criteria were gathered from histopathology examination review of all specimens. Significant correlation was found for all these findings except the hemorrhage (p = 0.071). A radiologic score of fifteen items variable between 0 and 18 was established. Miettinen risk classification was noted for each lesion. GISTs with very low risk had MSCT score < 4. GIST with low risk had a MSCT score between 5 and 9. GIST with moderate risk had a score between 10 and 14 and those with high risk had an MSCT score between 15 and 18. Significant correlation was found between the radiologic and histopathologic risk classification (p = 0. 001). Conclusion: MSCT is helpful in risk prediction for GIST.

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Section: Discussionmentioning

confidence: 99%