2008
DOI: 10.1016/j.juro.2008.03.133
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12-Year Outcomes Following Permanent Prostate Brachytherapy in Patients with Clinically Localized Prostate Cancer

Abstract: PPB offers acceptable 12-year BFR in patients who present with clinically localized prostate cancer. Implant dosimetry continues as an important predictor for BFR, while the addition of adjuvant therapies such as hormones and external radiation are insignificant. In patients who experience biochemical failure it appears that PSA doubling time is an important predictor of survival.

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Cited by 184 publications
(98 citation statements)
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“…Figure 1 shows how the same data from a patient may be interpreted using the current possible different definitions of failure. Postradical prostatectomy failure of treatment is usually defined as a PSA rise above 0.2 ng ml À1 , 19 in this case with the patient deemed as failing at 36 m. The ASTRO definition requires month 48 to have been reached before the patients is censured as failing at 33 m. The ASTROKattan, 20 ASTRO-last call 21 and Houston þ 2 definitions give the following times of failure 30, 48 and 54 m respectively. However, one-third of patients treated with brachytherapy will experience a PSA bounce within the first 3 years, typically of a magnitude of o4 ng ml À1 .…”
Section: Long-term Resultsmentioning
confidence: 99%
“…Figure 1 shows how the same data from a patient may be interpreted using the current possible different definitions of failure. Postradical prostatectomy failure of treatment is usually defined as a PSA rise above 0.2 ng ml À1 , 19 in this case with the patient deemed as failing at 36 m. The ASTRO definition requires month 48 to have been reached before the patients is censured as failing at 33 m. The ASTROKattan, 20 ASTRO-last call 21 and Houston þ 2 definitions give the following times of failure 30, 48 and 54 m respectively. However, one-third of patients treated with brachytherapy will experience a PSA bounce within the first 3 years, typically of a magnitude of o4 ng ml À1 .…”
Section: Long-term Resultsmentioning
confidence: 99%
“…12летняя выживаемость без прогрессирования составила почти 80 %. [12]. Эф фективность брахитерапии в монорежиме подтвердила и группа во главе с N. N. Stone -12летняя БРВ 79,2 % [13].…”
Section: Discussionunclassified
“…[17][18][19] Results have been mixed, with some studies suggesting some value and others no value to adding ADT to brachytherapy. 20,21 Data addressing the use of ADT with stereotactic RT are even more limited. Hopefully, with the completion of the RTOG 08-15 trial, the relative value of ADT in doseescalated RT for patients with intermediate-risk PCa will be answered.…”
Section: Long-term Aht Versus Rt Alonementioning
confidence: 99%