“…Griscelli's syndrome type 1 (GS1), a developmental disorder resulting from a mutation to the myosin Va heavy chain and characterized by severe neurologic deficits, including hypotonia, quadraparesis, marked motor developmental delay, mental retardation, seizures, and ataxia (Pastural et al, 1997;Ivanovich et al, 2001;Anikster et al, 2002;Sanal et al, 2002;Bahadoran et al, 2003), may be a product of impaired myelination (Kelton and Rauch, 1962;Winterbourn et al, 1971;Noguchi et al, 1983;Pastural et al, 1997;Anikster et al, 2002). In this report, we test whether myosin Va loss of function impairs oligodendrocyte morphogenesis and myelination in a GS1 mouse model, dilute-lethal, which possesses a myosin Va-null mutation (Mercer et al, 1991).…”