12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation

Moyo, Knowledge Mudhibadhi; Choi, Jieun; Chang, Jiyeon; Soedono, Shindy; Nguyet, Dan Vo Hoang; Song, Yuri; Park, Soo Jin; Go, Gyungchoon; Lee, Mi Kyung; Cho, Kae Won

doi:10.1016/j.jnutbio.2022.109127

Cited by 4 publications

(5 citation statements)

References 41 publications

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“…Specifically, 12-OAHSA inhibited IKKβ phosphorylation and prevented IκBα degradation, resulting in reduction of p65 phosphorylation. 30 12-OAHSA treatment significantly reduced aggregation of adipose macrophages and T lymphocytes in obese mice. And expression of proinflammatory cytokine genes and the NF-κB signaling pathway was decreased after 12-OAHSA treatment, whereas anti-inflammatory genes were increased in adipose tissue of mice.…”

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 87%

“…In vitro experiments demonstrated that 12‐OAHSA (oleic acid‐HSA) inhibited lipopolysaccharide (LPS)‐induced inflammatory responses in macrophages by inhibiting NF‐ κ B signaling pathway. Specifically, 12‐OAHSA inhibited IKK β phosphorylation and prevented I κ B α degradation, resulting in reduction of p65 phosphorylation 30 . 12‐OAHSA treatment significantly reduced aggregation of adipose macrophages and T lymphocytes in obese mice.…”

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 94%

“…12‐OAHSA treatment significantly reduced aggregation of adipose macrophages and T lymphocytes in obese mice. And expression of proinflammatory cytokine genes and the NF‐ κ B signaling pathway was decreased after 12‐OAHSA treatment, whereas anti‐inflammatory genes were increased in adipose tissue of mice 30 …”

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 96%

“…And expression of proinflammatory cytokine genes and the NF-κB signaling pathway was decreased after 12-OAHSA treatment, whereas anti-inflammatory genes were increased in adipose tissue of mice. 30 Recently, 9-PAHSA and 9-PAHPA were found to enhance conversion of white adipocytes to brown adipocytes in rosiglitazone-…”

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 99%

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Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity‐related diseases

Li,

Wang,

Jiao

et al. 2024

Obesity Reviews

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SummaryObesity, a burgeoning worldwide health system challenge, is associated with multiple chronic diseases, including diabetes and chronic inflammation. Fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified lipids with mitigating and anti‐inflammatory effects in diabetes. Increasing work has shown that FAHFAs exert antioxidant activity and enhance autophagy in neuronal cells and cardiomyocytes. We systematically summarized the biological activities of FAHFAs, including their regulatory effects on diabetes and inflammation, antioxidant activity, and autophagy augmentation. Notably, the structure–activity relationships and potential biosynthesis of FAHFAs are thoroughly discussed. FAHFAs also showed potential roles as diagnostic biomarkers. FAHFAs are a class of resources with promising applications in the biomedical field that require in‐depth research and hotspot development, as their structure has not been fully resolved and their biological activity has not been fully revealed.

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Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 87%

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 94%

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 96%

Section: Fahfas Inhibit Adipose Tissue and Intestinal Inflammationmentioning

confidence: 99%

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Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity‐related diseases

Li,

Wang,

Jiao

et al. 2024

Obesity Reviews

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“…Branched-chain FAHFAs are also known to be constituents of oils such as fish, corn, palm, soybean and olive oil. The highest concentration of 12-OAHSA, particularly, was monitored in olive oil [66]. FAHFAs are present in the majority of oils in concentrations of about 8-29 pmol/mg oil [67].…”

Section: Branched-chain Fahfamentioning

confidence: 97%

From Oxidized Fatty Acids to Dimeric Species: In Vivo Relevance, Generation and Methods of Analysis

Leopold,

Prabutzki,

Engel

et al. 2023

Molecules

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The occurrence of free fatty acids (FFAs) and the generation of reactive oxygen species (ROS) such as hydroxyl radicals (HO●) or hypochlorous acid (HOCl) is characteristic of inflammatory diseases, for instance, rheumatoid arthritis. Unsaturated fatty acids react with ROS yielding a variety of important products such as peroxides and chlorohydrins as primary and chain-shortened compounds (e.g., aldehydes and carboxylic acids) as secondary products. These modified fatty acids are either released from phospholipids by phospholipases or oxidatively modified subsequent to their release. There is increasing evidence that oligomeric products are also generated upon these processes. Fatty acid esters of hydroxy fatty acids (FAHFAs) are considered as very important products, but chlorinated compounds may be converted into dimeric and (with smaller yields) oligomeric products, as well. Our review is structured as follows: first, the different types of FFA oligomers known so far and the mechanisms of their putative generation are explained. Industrially relevant products as well as compounds generated from the frying of vegetable oils are also discussed. Second, the different opinions on whether dimeric fatty acids are considered as “friends” or “foes” are discussed.

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Exploring the Role of Fatty Acid Esters of Hydroxy Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease in Morbid Obese Women

Bertran,

Rusu,

Aguilar

et al. 2024

Preprint

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Background Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) present potential beneficial effects that could offer valuable insights into metabolic and inflammatory diseases. However, few FAHFAs have been studied and their role is unclear. Aims To assess FAHFA levels in individuals with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) associated with morbid obesity (MO) to explore the potential significance of FAHFAs in these conditions. Methods Using ultra-precise liquid chromatography, FAHFA serum levels were measured in 219 women, including 53 with normal weight (NW) and 166 with MO. The MO group was classified by histological diagnosis in 35 normal liver (NL), 38 simple steatosis (SS) and 93 metabolic dysfunction-associated steatohepatitis (MASH). Results 32 FAHFA isoforms from 11 families were identified. The most of FAHFAs presented low levels in MO, but tLAHOAs, LAHOA-1 and OAHOA-1 were increased. In MASLD, elevated tLAHPO, LAHPO-2, PAHLA-3 and PAHLA-4 levels were observed. In MASH, increased POHLA-1, tLAHPOs, LAHPO-2 and LAHLA-3, and decreased PAHSA-1, tOAHOAs, OAHSA-2 and OAHSA-3 levels were reported. Conclusion The study reveals novel insights into FAHFAs in a cohort of MO women with MASLD. In MASLD, we reported only increased levels of certain FAHFAs. In MASH, we found a different profile that could be characteristic.

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12-OAHSA is a component of olive oil and mitigates obesity-induced inflammation

Cited by 4 publications

References 41 publications

Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity‐related diseases

Fatty acid esters of hydroxy fatty acids: A potential treatment for obesity‐related diseases

From Oxidized Fatty Acids to Dimeric Species: In Vivo Relevance, Generation and Methods of Analysis

Exploring the Role of Fatty Acid Esters of Hydroxy Fatty Acids in Metabolic Dysfunction-Associated Steatotic Liver Disease in Morbid Obese Women

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