12-month follow-up results of high dose rosuvastatin loading before percutaneous coronary intervention in patients with acute coronary syndrome

Beneficial effects of statin treatment on coronary microvascular dysfunction and left ventricular remodeling in patients with acute myocardial infarction

“…Hong et al [23] reported that atorvastatin dose-dependently improves coronary flow reserve in AMI patients, as demonstrated using an intracoronary Doppler guidewire. Yun et al [24] also reported that pre-treatment with high-dose rosuvastatin (40 mg) significantly reduced major cardiovascular events at 12 months after the onset of acute coronary syndrome. Meanwhile, low-dose statin treatment has been shown to improve left ventricular dysfunction in Japanese patient populations; i.e., Teshima et al [16] and Ohara et al [17] reported that AMI patients benefit from atorvastatin 10 mg/day and pravastatin 10 mg/day, respectively.…”

Reporting in randomized trials published in International Journal of Cardiology in 2011 compared to the recommendations made in CONSORT 2010

“…Among the remaining 28 articles , 4 were excluded because they were cohort studies [6,7,9,12], and 4 additional non randomized controlled trials [5,10,19,24] were also excluded. Consequently, a total of 20 reports [2][3][4]8,11,[13][14][15][16][17][18][20][21][22][23][25][26][27][28][29] remained for analysis. Table 1 shows the detail of methodological quality evaluation according to CONSORT 2010 statement.…”

“…Meanwhile, there were nine trials (45%) reporting badly, only reporting 30% or less methodological items. The approach to estimation of sample size was reported in 9 (45%) articles [2][3][4]11,13,16,22,25,29]. Randomization methods were reported in four trials (20%) [22,[25][26][27], with all generated by computers.…”

“…The mechanism used to implement random allocation sequence was reported in two trials (10%), all using sequentially numbered sealed envelopes with a pre assigned random treatment [25,26]. Who enrolled participants, and who assigned participants were reported in 8 articles (40%) [2][3][4]11,13,[25][26][27]. Of all the articles, seven articles [2,4,14,[25][26][27]29] (35%) reported that all participants, including patients, care providers and result surveyors, were blinded.…”

“…Intention-to-treat analysis was adopted in eight articles [2,4,11,22,[25][26][27]29] (40%). Subgroup analyses and adjusted analyses were reported in six trials [3,4,11,13,14,27] (30%), all using linear or generalized linear model. Our study provides a comprehensive assessment of the design and reporting characteristics of PubMed indexed randomized controlled trials published in IJC in 2011 based on the CONSORT Statement 2010.…”