12-Hydroxycorniculatolide a from the Mangrove Tree, <i>Lumnitzera littorea</i>

Wongsomboon, Puttandon; Maneerat, Wisanu; Pyne, Stephen G.; Vittaya, Luksamee; Limtharakul, Thunwadee

doi:10.1177/1934578x1801301023

Cited by 4 publications

(4 citation statements)

References 6 publications

(7 reference statements)

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“…The accumulation of sulfates may be organ-specific. In case of the investigated Lumnitzera species, they are found in the roots, which normally are in contact with sea water, while they were not reported from studies on leaves and twigs [26,[29][30][31]. In this study, both species showed similar patterns of sulfated metabolites despite L. littorea is predominantly occurring at well-drained sites with less salinity, and typically growing as a tree, while L. racemosa is more resistant to saline conditions and occurs at the margin of bare salt pans [70] often growing as a shrub.…”

Section: Phytochemcial Analysesmentioning

confidence: 87%

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Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)

et al. 2021

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Lumnitzera littorea and Lumnitzera racemosa are mangrove species distributed widely along the Indonesian coasts. Besides their ecological importance, both are of interest owing to their wealth of natural products, some of which constitute potential sources for medicinal applications. We aimed to discover and characterize new anti-infective compounds, based on population-level sampling of both species from across the Indonesian Archipelago. Root metabolites were investigated by TLC, hyphenated LC-MS/MS and isolation, the internal transcribed spacer (ITS) region of rDNA was used for genetic characterization. Phytochemical characterization of both species revealed an unusual diversity in sulfated constituents with 3,3’,4’-tri-O-methyl-ellagic acid 4-sulfate representing the major compound in most samples. None of these compounds was previously reported for mangroves. Chemophenetic comparison of L. racemosa populations from different localities provided evolutionary information, as supported by molecular phylogenetic evidence. Samples of both species from particular locations exhibited anti-bacterial potential (Southern Nias Island and East Java against Gram-negative bacteria, Halmahera and Ternate Island against Gram-positive bacteria). In conclusion, Lumnitzera roots from natural mangrove stands represent a promising source for sulfated ellagic acid derivatives and further sulfur containing plant metabolites with potential human health benefits.

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Section: Phytochemcial Analysesmentioning

confidence: 87%

“…The extract of L. littorea leaves from Malaysia was reported to possess anti-microbial potential [29]. The leaf n-hexane extract of this species yielded triterpenes and sterols [30] whereas the twigs of L. littorea were described to contain macrocyclic lactones (represented by corniculatolide derivatives) and 6,7-dimethoxycoumarin [31].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)

et al. 2021

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“…[54] Compounds isolated from twigs of the plant (myrcetin and 12-hydroxycorniculatolide A) also showed moderate activity against S. aureus. [55] Significant antimicrobial activities were observed by the methanol, [56] acetone, [57] aqueous, [27] and ethanol extracts of the leaves and stem of Heritiera fomes along with the zinc and silver nanoparticles isolated from the bark. [4] Several studies were made on the antimicrobial potential of various extracts and their fractions from the leaf, [58] stem, [59] pneumatophores, [60] root, [61] and bark [62] of Excoecaria agallocha.…”

Section: Raimentioning

confidence: 99%

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Das

Jena

et al. 2022

Chemistry & Biodiversity

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Bhitarkanika National Park is the second largest contiguous mangrove forest of India. Approximately 0.15 million mangrove depending population are found residing in and around 307 villages within the National Park. Despite being one of the most diverse mangrove habitations of India, the ethnopharmacological practices are meager in comparison to the other mangrove regions of India and Southeast Asia. The present review is aimed to congregate information on the therapeutic potential and ethnopharmacology of nine dominant mangrove species of the National Park, such as Aegiceras corniculatum, Avicenia marina, Avicenia officinalis, Ceriops decandra, Excoecaria agallocha, Heritiera fomes, Lumnitzera racemosa, Rhizophora mucronata, and Sonneratia apetala. Our aim is to generate social awareness among the mangrove dwellers to promote uses of folklore medicine using these tremendously potential mangrove plants, as a complementary step to strengthen community health. Further, we also want to grab the attention of researchers working in related disciplines, for their holistic and extensive studies towards bio-prospectation of the dominant mangrove plants of Bhitarkanika National Park.

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“…In addition, the pure compounds of macrocyclic lactone and coumarin derivatives from the twig of L. littorea could scavenge free radicals because their structures contained many conjugated double bonds and oxygen as a substituent group, resulting in highly efficient free radical capture with lower IC50 values. 14 To increase the understanding of the antioxidant effect of methanol extracts of L.littorea bark, flower, leaf and twig, their phenolic and flavonoid compounds should be isolated and purified in future studies.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Bio-Activity Investigations of Extracts of Different Parts of Lumnitzera littorea Voigt

2020

TJNPR

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Plants are a great source of potentially beneficial chemical compounds. They produce a wide variety of substances that are used for biological functions and for preventing diseases caused by pathogens, fungi and other sources. Traditionally, it has been a common practice to treat microbial infections such as whooping cough, or skin ailments, and inflammations with crude extracts or decoctions derived from plants. However, there has been information of phenolic or flavonoid acting as bioactive substance but none of an obvious experimental result to determine the type of bioactive substance helping to treat the symptoms. Several previous works reported that different parts of plants including bark, leaves, fruits, flowers, and seeds have phytochemical constituents with a variety of pharmacological properties. 1-4 These phytochemicals contain naturally bioactive compounds that are formed during a plant's normal metabolic processes and which are often referred to as secondary metabolites. These metabolites commonly include alkaloids, terpenoids, tannins, saponins, phenolics and flavonoids. These are widely used as lipase inhibitors, antioxidants and antimicrobial agents. 1-6 To identify bioactive compounds, phytochemical screening is the first and important step in isolating the type of secondary

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12-Hydroxycorniculatolide a from the Mangrove Tree, Lumnitzera littorea

Cited by 4 publications

References 6 publications

Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)

Analysis of Unusual Sulfated Constituents and Anti-infective Properties of Two Indonesian Mangroves, Lumnitzera littorea and Lumnitzera racemosa (Combretaceae)

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

Bio-Activity Investigations of Extracts of Different Parts of Lumnitzera littorea Voigt

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